Institutes for Systems Genetics, West China Hospital
Copyright @ 2022 ISG. All Rights Reserved.
ncRNA name
UCA1
Specific or universal ncRNAs
Universal ncRNAs
Class
Long noncoding RNA
Biomarker
Yes
Biomarker application
Upstream regulatory factors
Not available
Downstream target
Wnt/Ī²-catenin signaling pathway
Cancer name
Glioma
Cancer site
Brain, Central Nervous System
Treatment type
Chemotherapy
Drug
Cisplatin/Temozolomide
Impact of wild-type ncRNA on chemotherapy resistance
Impact of knockdown of ncRNA on chemotherapy resistance
Impact of overexpression of ncRNA on chemotherapy resistance
Up
ncRNA differential expression in
cancer
patients vs. healthy people
Up
Number of patients
Not available
Male patients
Not available
Female patients
Not available
Age range and number
Not available
PMID
Description
The aberrant expression of UCA1 was associated with chemo-resistance to cisplatin and temozolomide in glioma cells via interacting with Wnt/Ī²-catenin signaling.
Tissue resource
glioma tissues and adjacent normal brain tissues
glioma cell lines SHG44
glioma cell lines U251
glioma cell lines U87
glioma cell lines SHG139
Experiment
qRT-PCR,Western blot
Institute
the First Teaching Hospital of Jilin University
American Type Culture Collection
Country
China
USA
Continent
Asia
North American
Institutes for Systems Genetics, West China Hospital
Copyright @ 2022 ISG. All Rights Reserved.