TTN-AS1

ncRNA information

ncRNA name

TTN-AS1

Specific or universal ncRNAs

Specific ncRNAs

Class

Long noncoding RNA

Biomarker

No

Biomarker application

Upstream regulatory factors

Not available

Downstream target

miR-134-5p/MBTD1

Cancer information

Cancer name

Osteosarcoma

Cancer site

Bone, Articular Cartilage

Treatment information

Treatment type

Chemotherapy

Drug

Cisplatin

Impact of wild-type ncRNA on chemotherapy resistance

Impact of knockdown of ncRNA on chemotherapy resistance

Down

Impact of overexpression of ncRNA on chemotherapy resistance

Clinical Information

ncRNA differential expression in
cancer patients vs. healthy people

Up

Number of patients

Not available

Male patients

Not available

Female patients

Not available

Age range and number

Not available

Research information

PMID

Description

MBTD1 promoted cell viability and inhibited apoptosis, and knockdown of MBTD1 reversed the cancer-promoting effects of lncRNA TTN-AS1. Downregulation of lncRNA TTN-AS1 reduced drug resistance.

Tissue resource

osteosarcoma tissues and adjacent tissues

human osteoblast cell lines hFOB 1.19

human osteosarcoma cell lines Saos-2

human osteosarcoma cell lines U-2OS

Experiment

qRT-PCR,Western blot,Luciferase reporter assay


Institute

Alenabio Biotechnology Co., Ltd.

American Type Culture Collection

Country

China

USA

Continent

Asia

North American