hsa-miR-374a-5p

ncRNA information

ncRNA name

hsa-miR-374a-5p

Specific or universal ncRNAs

Specific ncRNAs

Class

MicroRNA

Biomarker

Yes

Biomarker application

Diagnosis/Treatment

Upstream regulatory factors

Not available

Downstream target

Not available

Cancer information

Cancer name

Gastric Cancer

Cancer site

Stomach

Treatment information

Treatment type

Chemotherapy

Drug

Cisplatin

Impact of wild-type ncRNA on chemotherapy resistance

Impact of knockdown of ncRNA on chemotherapy resistance

Down

Impact of overexpression of ncRNA on chemotherapy resistance

Clinical Information

ncRNA differential expression in
cancer patients vs. healthy people

Up

Number of patients

59

Male patients

41

Female patients

18

Age range and number

11(<=60)+48(>60)

Research information

PMID

Description

MiR-374a-5p overexpression promoted while miR-374a-5p knockdown inhibited gastric cancer chemoresistance in vitro and in vivo.

Tissue resource

serum samples from gastric cancer patients and healthy donors

human gastric cancer cell lines MGC-803

human gastric cancer cell lines SGC-7901

human gastric cancer cell lines HGC-27

human embryonic kidney cell lines HEK-293T

Experiment

qRT-PCR,Western blot,Luciferase reporter assay


Institute

the Affiliated People's Hospital of Jiangsu University

Country

China

Continent

Asia