Institutes for Systems Genetics, West China Hospital
Copyright @ 2022 ISG. All Rights Reserved.
ncRNA name
hsa-miR-374a-5p
Specific or universal ncRNAs
Specific ncRNAs
Class
MicroRNA
Biomarker
Yes
Biomarker application
Diagnosis/Treatment
Upstream regulatory factors
Not available
Downstream target
Not available
Cancer name
Gastric Cancer
Cancer site
Stomach
Treatment type
Chemotherapy
Drug
Cisplatin
Impact of wild-type ncRNA on chemotherapy resistance
Impact of knockdown of ncRNA on chemotherapy resistance
Down
Impact of overexpression of ncRNA on chemotherapy resistance
ncRNA differential expression in
cancer
patients vs. healthy people
Up
Number of patients
59
Male patients
41
Female patients
18
Age range and number
11(<=60)+48(>60)
PMID
Description
MiR-374a-5p overexpression promoted while miR-374a-5p knockdown inhibited gastric cancer chemoresistance in vitro and in vivo.
Tissue resource
serum samples from gastric cancer patients and healthy donors
human gastric cancer cell lines MGC-803
human gastric cancer cell lines SGC-7901
human gastric cancer cell lines HGC-27
human embryonic kidney cell lines HEK-293T
Experiment
qRT-PCR,Western blot,Luciferase reporter assay
Institute
the Affiliated People's Hospital of Jiangsu University
Country
China
Continent
Asia
Institutes for Systems Genetics, West China Hospital
Copyright @ 2022 ISG. All Rights Reserved.