SBF2-AS1

ncRNA information

ncRNA name

SBF2-AS1

Specific or universal ncRNAs

Specific ncRNAs

Class

Long noncoding RNA

Biomarker

No

Biomarker application

Upstream regulatory factors

Not available

Downstream target

TWF1

Cancer information

Cancer name

Pancreatic Cancer

Cancer site

Pancreas

Treatment information

Treatment type

Chemotherapy

Drug

Gemcitabine

Impact of wild-type ncRNA on chemotherapy resistance

Impact of knockdown of ncRNA on chemotherapy resistance

Down

Impact of overexpression of ncRNA on chemotherapy resistance

Clinical Information

ncRNA differential expression in
cancer patients vs. healthy people

Up

Number of patients

82

Male patients

51

Female patients

31

Age range and number

33(<60)+49(>=60)

Research information

PMID

Description

Knock-down of SBF2-AS1 inhibits the expression of TWF1 by competitively binding with miR-142-3p to induce gemcitabine resistance in pancreatic cancer.

Tissue resource

pancreatic cancer tissues

pancreatic cancer cell lines AsPC-1

pancreatic cancer cell lines HPAC

pancreatic cancer cell lines BxPC-3

pancreatic cancer cell lines PANC-1

normal pancreatic ductal epithelial cell lines HPDE6-C7

Experiment

qRT-PCR,Western blot,Dual-Luciferase reporter assay


Institute

Fudan University Shanghai Cancer Center

American Type Culture Collection

Country

China

USA

Continent

Asia

North American