Institutes for Systems Genetics, West China Hospital
Copyright @ 2022 ISG. All Rights Reserved.
ncRNA name
SBF2-AS1
Specific or universal ncRNAs
Specific ncRNAs
Class
Long noncoding RNA
Biomarker
No
Biomarker application
Upstream regulatory factors
Not available
Downstream target
TWF1
Cancer name
Pancreatic Cancer
Cancer site
Pancreas
Treatment type
Chemotherapy
Drug
Gemcitabine
Impact of wild-type ncRNA on chemotherapy resistance
Impact of knockdown of ncRNA on chemotherapy resistance
Down
Impact of overexpression of ncRNA on chemotherapy resistance
ncRNA differential expression in
cancer
patients vs. healthy people
Up
Number of patients
82
Male patients
51
Female patients
31
Age range and number
33(<60)+49(>=60)
PMID
Description
Knock-down of SBF2-AS1 inhibits the expression of TWF1 by competitively binding with miR-142-3p to induce gemcitabine resistance in pancreatic cancer.
Tissue resource
pancreatic cancer tissues
pancreatic cancer cell lines AsPC-1
pancreatic cancer cell lines HPAC
pancreatic cancer cell lines BxPC-3
pancreatic cancer cell lines PANC-1
normal pancreatic ductal epithelial cell lines HPDE6-C7
Experiment
qRT-PCR,Western blot,Dual-Luciferase reporter assay
Institute
Fudan University Shanghai Cancer Center
American Type Culture Collection
Country
China
USA
Continent
Asia
North American
Institutes for Systems Genetics, West China Hospital
Copyright @ 2022 ISG. All Rights Reserved.