Institutes for Systems Genetics, West China Hospital
Copyright @ 2022 ISG. All Rights Reserved.
ncRNA name
hsa_circ_0076305
Specific or universal ncRNAs
Specific ncRNAs
Class
Circular RNA
Biomarker
Yes
Biomarker application
Treatment
Upstream regulatory factors
Not available
Downstream target
miR-296-5p/STAT3
Cancer name
Non-Small Cell Lung Cancer
Cancer site
Lung
Treatment type
Chemotherapy
Drug
Cisplatin
Impact of wild-type ncRNA on chemotherapy resistance
Up
Impact of knockdown of ncRNA on chemotherapy resistance
Impact of overexpression of ncRNA on chemotherapy resistance
ncRNA differential expression in
cancer
patients vs. healthy people
Up
Number of patients
Not available
Male patients
Not available
Female patients
Not available
Age range and number
Not available
PMID
Description
Circ_0076305 regulated STAT3 expression and DDP resistance of NSCLC cells via sponging miR-296-5p. Results suggested knockdown of circ_0076305 might provide an effective approach for NSCLC treatment strategy.
Tissue resource
non-small cell lung cancer tumor and normal specimens
human normal pulmonary epithelial cell lines BEAS-2B
non-small cell lung cancer cell lines A549
non-small cell lung cancer cell lines H1650
Experiment
qRT-PCR,Western blot
Institute
the Second Affiliated Hospital of Xi'an Jiaotong University
the Cell Resource Center of Chinese Academy of Sciences
Country
China
Continent
Asia
Institutes for Systems Genetics, West China Hospital
Copyright @ 2022 ISG. All Rights Reserved.