hsa_circ_0076305

ncRNA information

ncRNA name

hsa_circ_0076305

Specific or universal ncRNAs

Specific ncRNAs

Class

Circular RNA

Biomarker

Yes

Biomarker application

Treatment

Upstream regulatory factors

Not available

Downstream target

miR-296-5p/STAT3

Cancer information

Cancer name

Non-Small Cell Lung Cancer

Cancer site

Lung

Treatment information

Treatment type

Chemotherapy

Drug

Cisplatin

Impact of wild-type ncRNA on chemotherapy resistance

Up

Impact of knockdown of ncRNA on chemotherapy resistance

Impact of overexpression of ncRNA on chemotherapy resistance

Clinical Information

ncRNA differential expression in
cancer patients vs. healthy people

Up

Number of patients

Not available

Male patients

Not available

Female patients

Not available

Age range and number

Not available

Research information

PMID

Description

Circ_0076305 regulated STAT3 expression and DDP resistance of NSCLC cells via sponging miR-296-5p. Results suggested knockdown of circ_0076305 might provide an effective approach for NSCLC treatment strategy.

Tissue resource

non-small cell lung cancer tumor and normal specimens

human normal pulmonary epithelial cell lines BEAS-2B

non-small cell lung cancer cell lines A549

non-small cell lung cancer cell lines H1650

Experiment

qRT-PCR,Western blot


Institute

the Second Affiliated Hospital of Xi'an Jiaotong University

the Cell Resource Center of Chinese Academy of Sciences

Country

China

Continent

Asia