Institutes for Systems Genetics, West China Hospital
Copyright @ 2022 ISG. All Rights Reserved.
ncRNA name
MALAT1
Specific or universal ncRNAs
Universal ncRNAs
Class
Long noncoding RNA
Biomarker
No
Biomarker application
Upstream regulatory factors
Not available
Downstream target
miR-101-3p/VEGF-C
Cancer name
Bladder Cancer
Cancer site
Bladder
Treatment type
Chemotherapy
Drug
Cisplatin
Impact of wild-type ncRNA on chemotherapy resistance
Impact of knockdown of ncRNA on chemotherapy resistance
Up
Impact of overexpression of ncRNA on chemotherapy resistance
ncRNA differential expression in
cancer
patients vs. healthy people
Not available
Number of patients
Not available
Male patients
Not available
Female patients
Not available
Age range and number
Not available
PMID
Description
We found that suppression of MALAT1 enhanced the chemotherapeutic drug sensitivity and inhibited the cisplatin resistance of the BC cells.
Tissue resource
bladder cancer tissues and adjacent normal tissues
human bladder epithelial immortalized cell lines SVHUC-1
human bladder cancer cell lines 5637
human bladder cancer cell lines EJ-M3
human bladder cancer cell lines T24
Experiment
qRT-PCR,Western blot,Luciferase reporter assay
Institute
the Xiangya Hospital, Central South University
American Type Culture Collection
Country
China
USA
Continent
Asia
Amercia
Institutes for Systems Genetics, West China Hospital
Copyright @ 2022 ISG. All Rights Reserved.