MALAT1

ncRNA information

ncRNA name

MALAT1

Specific or universal ncRNAs

Universal ncRNAs

Class

Long noncoding RNA

Biomarker

No

Biomarker application

Upstream regulatory factors

Not available

Downstream target

miR-101-3p/VEGF-C

Cancer information

Cancer name

Bladder Cancer

Cancer site

Bladder

Treatment information

Treatment type

Chemotherapy

Drug

Cisplatin

Impact of wild-type ncRNA on chemotherapy resistance

Impact of knockdown of ncRNA on chemotherapy resistance

Up

Impact of overexpression of ncRNA on chemotherapy resistance

Clinical Information

ncRNA differential expression in
cancer patients vs. healthy people

Not available

Number of patients

Not available

Male patients

Not available

Female patients

Not available

Age range and number

Not available

Research information

PMID

Description

We found that suppression of MALAT1 enhanced the chemotherapeutic drug sensitivity and inhibited the cisplatin resistance of the BC cells.

Tissue resource

bladder cancer tissues and adjacent normal tissues

human bladder epithelial immortalized cell lines SVHUC-1

human bladder cancer cell lines 5637

human bladder cancer cell lines EJ-M3

human bladder cancer cell lines T24

Experiment

qRT-PCR,Western blot,Luciferase reporter assay


Institute

the Xiangya Hospital, Central South University

American Type Culture Collection

Country

China

USA

Continent

Asia

Amercia