Institutes for Systems Genetics, West China Hospital
Copyright @ 2022 ISG. All Rights Reserved.
ncRNA name
hsa-miR-421
Specific or universal ncRNAs
Universal ncRNAs
Class
MicroRNA
Biomarker
Yes
Biomarker application
Treatment
Upstream regulatory factors
Not available
Downstream target
KEAP1
Cancer name
Non-Small Cell Lung Cancer
Cancer site
Lung
Treatment type
Chemotherapy
Drug
Paclitaxel
Impact of wild-type ncRNA on chemotherapy resistance
Impact of knockdown of ncRNA on chemotherapy resistance
Down
Impact of overexpression of ncRNA on chemotherapy resistance
ncRNA differential expression in
cancer
patients vs. healthy people
Not available
Number of patients
Not available
Male patients
Not available
Female patients
Not available
Age range and number
Not available
PMID
Description
Knockdown of miR-421 expression with an antisense morpholino oligonucleotide (AMO) increased ROS levels and treatment sensitivity to paclitaxel in vitro and in vivo.
Tissue resource
non-small cell lung cancer tissue specimens
human normal lung epithelial and fibroblast cell lines BEAS-2B
human normal lung epithelial and fibroblast cell lines CCD19-lu
human non-small cell lung cancer cell lines A549
human non-small cell lung cancer cell lines H358
human non-small cell lung cancer cell lines H1650
human non-small cell lung cancer cell lines H460
human non-small cell lung cancer cell lines H1975
Experiment
qRT-PCR,Western blot,Luciferase reporter assay
Institute
the Taihe Hospital
American Type Culture Collection
Country
China
USA
Continent
Asia
North American
Institutes for Systems Genetics, West China Hospital
Copyright @ 2022 ISG. All Rights Reserved.