NEAT1

ncRNA information

ncRNA name

NEAT1

Specific or universal ncRNAs

Universal ncRNAs

Class

Long noncoding RNA

Biomarker

No

Biomarker application

Upstream regulatory factors

Not available

Downstream target

miR-34a-5p/miR-204-5p

Cancer information

Cancer name

Prostate Cancer

Cancer site

Prostate

Treatment information

Treatment type

Chemotherapy

Drug

Docetaxel

Impact of wild-type ncRNA on chemotherapy resistance

Up

Impact of knockdown of ncRNA on chemotherapy resistance

Impact of overexpression of ncRNA on chemotherapy resistance

Clinical Information

ncRNA differential expression in
cancer patients vs. healthy people

Not available

Number of patients

Not available

Male patients

Not available

Female patients

Not available

Age range and number

Not available

Research information

PMID

Description

We concluded that NEAT1 contributes to the docetaxel resistance by increasing ACSL4 via sponging miR-34a-5p and miR-204-5p in PCa cells.

Tissue resource

primary and metastatic prostate cancer tissue samples

human prostate cancer cell lines PC3

human prostate cancer cell lines DU145

human embryonic kidney cell lines HEK-293T

Experiment

qRT-PCR,Western blot,Dual-Luciferase reporter assay


Institute

the Second Hospital of Tianjin Medical University

American Type Culture Collection

Country

China

USA

Continent

Asia

North American