OIP5-AS1

ncRNA information

ncRNA name

OIP5-AS1

Specific or universal ncRNAs

Universal ncRNAs

Class

Long noncoding RNA

Biomarker

None

Biomarker application

Upstream regulatory factors

Not available

Downstream target

miR-30e-5p/ATG12

Cancer information

Cancer name

Chronic Myeloid Leukemia

Cancer site

qRT-PCR,Western blot,Dual-luciferase assay

Treatment information

Treatment type

Chemotherapy

Drug

Imatinib

Impact of wild-type ncRNA on chemotherapy resistance

Up

Impact of knockdown of ncRNA on chemotherapy resistance

Impact of overexpression of ncRNA on chemotherapy resistance

Clinical Information

ncRNA differential expression in
cancer patients vs. healthy people

Not available

Number of patients

Not available

Male patients

Not available

Female patients

Not available

Age range and number

Not available

Research information

PMID

Description

Our study reveals that OIP5-AS1 promotes the autophagy-related IM resistance in CML cells by regulating miR-30e-5p/ATG12 axis, providing new insights into the drug resistance mechanism of CML

Tissue resource

bone marrow of normal individuals and chronic myeloid leukemia patients

human chronic myeloid leukemia cell line K562

human BCR-ABL-non-expressing cell line 293T

Experiment

None


Institute

the second affiliated hospital of Chongqing Medical University

the Cell Bank of Shanghai Institute of Cell Biology

Country

China

China

Continent

Asia

Asia