Institutes for Systems Genetics, West China Hospital
Copyright @ 2022 ISG. All Rights Reserved.
ncRNA name
AFAP1-AS1
Specific or universal ncRNAs
Specific ncRNAs
Class
Long noncoding RNA
Biomarker
No
Biomarker application
Upstream regulatory factors
Not available
Downstream target
miR-139-5p/RRM2
Cancer name
Non-Small Cell Lung Cancer
Cancer site
Lung
Treatment type
Chemotherapy
Drug
5-Fluorouracil/Cisplatin/Adriamycin/Paclitaxel
Impact of wild-type ncRNA on chemotherapy resistance
Up
Impact of knockdown of ncRNA on chemotherapy resistance
Impact of overexpression of ncRNA on chemotherapy resistance
ncRNA differential expression in
cancer
patients vs. healthy people
Up
Number of patients
Not available
Male patients
Not available
Female patients
Not available
Age range and number
Not available
PMID
Description
AFAP1-AS1 promoted chemotherapy resistance by supressing miR-139-5p expression and promoting RRM2/EGFR/AKT signaling pathway in NSCLC cells.
Tissue resource
non-small cell lung cancer tissues
non-small cell lung cancer cell lines H1975
non-small cell lung cancer cell lines PC-9
non-small cell lung cancer cell lines A549
non-small cell lung cancer cell lines SPC-1
human normal lung epithelial cell lines BEAS-2B
Experiment
qRT-PCR,Western blot,Luciferase reporter assay
Institute
the First Affliated Hospital of Chengdu Medical College
the Institute of Biochemistry and Cell Biology of the Chinese Academy of Sciences
Country
China
Continent
Asia
Institutes for Systems Genetics, West China Hospital
Copyright @ 2022 ISG. All Rights Reserved.