Institutes for Systems Genetics, West China Hospital
Copyright @ 2022 ISG. All Rights Reserved.
ncRNA name
hsa-miR-182-5p
Specific or universal ncRNAs
Specific ncRNAs
Class
MicroRNA
Biomarker
Yes
Biomarker application
Treatment
Upstream regulatory factors
Not available
Downstream target
GLI2
Cancer name
Lung Adenocarcinoma
Cancer site
Lung
Treatment type
Chemotherapy
Drug
Cisplatin
Impact of wild-type ncRNA on chemotherapy resistance
Down
Impact of knockdown of ncRNA on chemotherapy resistance
Impact of overexpression of ncRNA on chemotherapy resistance
ncRNA differential expression in
cancer
patients vs. healthy people
Not available
Number of patients
Not available
Male patients
Not available
Female patients
Not available
Age range and number
Not available
PMID
Description
The miR-182-5p/GLI2 modulates tumorigenesis and cisplatin-resistance in LADC cells, by influencing the HHSP.
Tissue resource
lung cancer tissue samples
human parental lung adenocarcinoma cell lines NCI-H460
human parental lung adenocarcinoma cell lines A549
lung adenocarcinoma cisplatin-resistant cell lines CisR
Experiment
qRT-PCR,Luciferase reporter assay
Institute
Medical University of Graz
Trinity College
Country
Austria
Ireland
Continent
Europe
Institutes for Systems Genetics, West China Hospital
Copyright @ 2022 ISG. All Rights Reserved.