UCA1

ncRNA information

ncRNA name

UCA1

Specific or universal ncRNAs

Universal ncRNAs

Class

Long noncoding RNA

Biomarker

Yes

Biomarker application

Treatment

Upstream regulatory factors

Not available

Downstream target

miR-513a-5p

Cancer information

Cancer name

Retinoblastoma Cancer

Cancer site

Eye

Treatment information

Treatment type

Chemotherapy

Drug

5-Fluorouracil/Carboplatin/Cisplatin/Etoposide/Vincristine

Impact of wild-type ncRNA on chemotherapy resistance

Impact of knockdown of ncRNA on chemotherapy resistance

Down

Impact of overexpression of ncRNA on chemotherapy resistance

Clinical Information

ncRNA differential expression in
cancer patients vs. healthy people

Not available

Number of patients

Not available

Male patients

Not available

Female patients

Not available

Age range and number

Not available

Research information

PMID

Description

Knockdown of UCA1 remarkably inhibited proliferation and sensitized retinoblastoma cells to multiple chemotherapy drugs.

Tissue resource

retinoblastoma tissues

human retinoblastoma cell lines SO-RB50

human embryonic kidney cell lines HEK-293T

human retinoblastoma vincristine-resistant cell lines SO-RB50/VCR

human retinoblastoma carboplatin-resistant cell lines SO-RB50/CBP

Experiment

qRT-PCR,Western blot,Luciferase reporter assay


Institute

the Cangzhou Central Hospital

American Type Culture Collection

the Chinese Academy of Sciences Cell Bank

Country

China

USA

China

Continent

Asia

North American

Asia