Institutes for Systems Genetics, West China Hospital
Copyright @ 2022 ISG. All Rights Reserved.
ncRNA name
UCA1
Specific or universal ncRNAs
Universal ncRNAs
Class
Long noncoding RNA
Biomarker
Yes
Biomarker application
Treatment
Upstream regulatory factors
Not available
Downstream target
miR-513a-5p
Cancer name
Retinoblastoma Cancer
Cancer site
Eye
Treatment type
Chemotherapy
Drug
5-Fluorouracil/Carboplatin/Cisplatin/Etoposide/Vincristine
Impact of wild-type ncRNA on chemotherapy resistance
Impact of knockdown of ncRNA on chemotherapy resistance
Down
Impact of overexpression of ncRNA on chemotherapy resistance
ncRNA differential expression in
cancer
patients vs. healthy people
Not available
Number of patients
Not available
Male patients
Not available
Female patients
Not available
Age range and number
Not available
PMID
Description
Knockdown of UCA1 remarkably inhibited proliferation and sensitized retinoblastoma cells to multiple chemotherapy drugs.
Tissue resource
retinoblastoma tissues
human retinoblastoma cell lines SO-RB50
human embryonic kidney cell lines HEK-293T
human retinoblastoma vincristine-resistant cell lines SO-RB50/VCR
human retinoblastoma carboplatin-resistant cell lines SO-RB50/CBP
Experiment
qRT-PCR,Western blot,Luciferase reporter assay
Institute
the Cangzhou Central Hospital
American Type Culture Collection
the Chinese Academy of Sciences Cell Bank
Country
China
USA
China
Continent
Asia
North American
Asia
Institutes for Systems Genetics, West China Hospital
Copyright @ 2022 ISG. All Rights Reserved.