Institutes for Systems Genetics, West China Hospital
Copyright @ 2022 ISG. All Rights Reserved.
ncRNA name
SNHG14
Specific or universal ncRNAs
Universal ncRNAs
Class
Long noncoding RNA
Biomarker
No
Biomarker application
Upstream regulatory factors
Not available
Downstream target
miR-186/ATG14
Cancer name
Colorectal Cancer
Cancer site
Colon, Rectum, and Anus
Treatment type
Chemotherapy
Drug
Cisplatin
Impact of wild-type ncRNA on chemotherapy resistance
Up
Impact of knockdown of ncRNA on chemotherapy resistance
Impact of overexpression of ncRNA on chemotherapy resistance
ncRNA differential expression in
cancer
patients vs. healthy people
Not available
Number of patients
Not available
Male patients
Not available
Female patients
Not available
Age range and number
Not available
PMID
Description
The novel of SNHG14/miR-186/ATG14 could play a vital role in regulating CRC cell progression. Moreover, this showed its clinical potential in regulating cisplatin resistance during CRC treatment.
Tissue resource
colorectal cancer tissues and the adjacent normal tissues
human colorectal cancer cell lines SW620
human colorectal cancer cell lines SW480
normal human colon mucosal epithelial cell lines NCM460
human embryonic kidney cell lines HEK-293T
paired colorectal cancer tissues and the adjacent normal tissues
human colorectal cancer cell lines SW620
human colorectal cancer cell lines SW480
normal human colon mucosal epithelial cell lines NCM460
human embryonic kidney cell lines 293-T
Experiment
qRT-PCR,Luciferase reporter assay
Institute
the Shanghai RuiJin hospital
American Type Culture Collection
American Type Culture Collection
Country
China
USA
United States
Continent
Asia
North American
North Amercian
Institutes for Systems Genetics, West China Hospital
Copyright @ 2022 ISG. All Rights Reserved.