MIR17HG

ncRNA information

ncRNA name

MIR17HG

Specific or universal ncRNAs

Specific ncRNAs

Class

Long noncoding RNA

Biomarker

Yes

Biomarker application

Treatment

Upstream regulatory factors

Not available

Downstream target

miR-130a-3p

Cancer information

Cancer name

Osteosarcoma

Cancer site

Bone, Articular Cartilage

Treatment information

Treatment type

Chemotherapy

Drug

Cisplatin

Impact of wild-type ncRNA on chemotherapy resistance

Up

Impact of knockdown of ncRNA on chemotherapy resistance

Impact of overexpression of ncRNA on chemotherapy resistance

Clinical Information

ncRNA differential expression in
cancer patients vs. healthy people

Up

Number of patients

Not available

Male patients

Not available

Female patients

Not available

Age range and number

Not available

Research information

PMID

Description

MIR17HG promoted the proliferation, invasion and cisplatin resistance of OS cells in vitro, and the MIR17HG knockdown inhibited the growth in vivo.

Tissue resource

osteosarcoma specimens and corresponding normal bone tissues

osteosarcoma cell lines Saos-2

osteosarcoma cell lines U2-OS

osteosarcoma cell lines 143 B

osteosarcoma cell lines MG63

normal osteoblastic cell lines hFOB

Experiment

qRT-PCR,Western blot,Luciferase reporter assay


Institute

the Hong Hui Hospital of Xi'an Jiao Tong University

Type Culture Collection Centre

Country

China

Continent

Asia