Institutes for Systems Genetics, West China Hospital
Copyright @ 2022 ISG. All Rights Reserved.
ncRNA name
DDX11-AS1
Specific or universal ncRNAs
Universal ncRNAs
Class
Long noncoding RNA
Biomarker
Yes
Biomarker application
Treatment
Upstream regulatory factors
Not available
Downstream target
TAF1/TOP2A
Cancer name
Esophageal Cancer
Cancer site
Esophagus
Treatment type
Chemotherapy
Drug
Paclitaxel
Impact of wild-type ncRNA on chemotherapy resistance
Impact of knockdown of ncRNA on chemotherapy resistance
Down
Impact of overexpression of ncRNA on chemotherapy resistance
ncRNA differential expression in
cancer
patients vs. healthy people
Not available
Number of patients
Not available
Male patients
Not available
Female patients
Not available
Age range and number
Not available
PMID
Description
DDX11-AS1 knockdown results in reduced resistance of EC cells to PTX by inhibiting TOP2A transcription via TAF1.
Tissue resource
esophageal cancer tissues and adjacent normal tissues
human embryonic kidney cell lines HEK-293T
esophageal cancer cell lines EC109
esophageal cancer cell lines KYSE150
Experiment
qRT-PCR,Western blot,Dual-Luciferase reporter assay
Institute
the Cancer Hospital of Shantou University Medical College
the Cell Bank of Chinese Academy of Sciences
American Type Culture Collection
Country
China
USA
Continent
Asia
North American
Institutes for Systems Genetics, West China Hospital
Copyright @ 2022 ISG. All Rights Reserved.