Institutes for Systems Genetics, West China Hospital
Copyright @ 2022 ISG. All Rights Reserved.
ncRNA name
NCK1-AS1
Specific or universal ncRNAs
Universal ncRNAs
Class
Long noncoding RNA
Biomarker
No
Biomarker application
Upstream regulatory factors
Not available
Downstream target
miR-137/TRIM24
Cancer name
Glioma
Cancer site
Brain, Central Nervous System
Treatment type
Chemotherapy
Drug
Temozolomide
Impact of wild-type ncRNA on chemotherapy resistance
Up
Impact of knockdown of ncRNA on chemotherapy resistance
Impact of overexpression of ncRNA on chemotherapy resistance
ncRNA differential expression in
cancer
patients vs. healthy people
Not available
Number of patients
36
Male patients
23
Female patients
13
Age range and number
Not available
PMID
Description
NCK1-AS1 could increase drug resistance of glioma cells to TMZ by modulating miR-137/TRIM24 pathway.
Tissue resource
fresh original glioma tissues
recurrent glioma tissues
human glioma cell lines U251
human glioma cell lines A172
human glioma transformed cell lines HEK-293
Experiment
qRT-PCR,Western blot,Dual-Luciferase reporter assay
Institute
the Second Affiliated Hospital of Xi'an Medical University
Procell Life Science & Technology Co., Ltd
Country
China
China
Continent
Asia
Asia
Institutes for Systems Genetics, West China Hospital
Copyright @ 2022 ISG. All Rights Reserved.