hsa-miR-302a

ncRNA information

ncRNA name

hsa-miR-302a

Specific or universal ncRNAs

Specific ncRNAs

Class

MicroRNA

Biomarker

Yes

Biomarker application

Prognosis

Upstream regulatory factors

Not available

Downstream target

NFIB/CD44

Cancer information

Cancer name

Colorectal Cancer

Cancer site

Colon, Rectum, and Anus

Treatment information

Treatment type

Chemotherapy

Drug

Cetuximab

Impact of wild-type ncRNA on chemotherapy resistance

Down

Impact of knockdown of ncRNA on chemotherapy resistance

Impact of overexpression of ncRNA on chemotherapy resistance

Clinical Information

ncRNA differential expression in
cancer patients vs. healthy people

Down

Number of patients

Not available

Male patients

Not available

Female patients

Not available

Age range and number

Not available

Research information

PMID

Description

MiR-302a acts as a multifaceted regulator of CRC metastasis and CTX resistance by targeting NFIB and CD44, respectively.

Tissue resource

fresh paired human colorectal cancer tissues and the corresponding adjacent nontumorous colorectal tissues

human colorectal cancer cell lines HCT116

human colorectal cancer cell lines DiFi

human colorectal cancer cell lines HCT8

human colorectal cancer cell lines HT29

human colorectal cancer cell lines LoVo

human colorectal cancer cell lines RKO

human colorectal cancer cell lines DLD-1

human colorectal cancer cell lines SW620

human colorectal cancer cell lines SW480

human colorectal cancer cell lines Caco-2

human colorectal cancer cell lines SW1463

human colorectal cancer cell lines T84

human colorectal cancer cell lines SW948

normal human intestinal epithelial cell lines HIEC

Experiment

qRT-PCR,Dual-Luciferase reporter assay


Institute

Xijing Hospital of Digestive Diseases

American Type Culture Collection

Country

China

USA

Continent

Asia

North American