Institutes for Systems Genetics, West China Hospital
Copyright @ 2022 ISG. All Rights Reserved.
ncRNA name
hsa-miR-302a
Specific or universal ncRNAs
Specific ncRNAs
Class
MicroRNA
Biomarker
Yes
Biomarker application
Prognosis
Upstream regulatory factors
Not available
Downstream target
NFIB/CD44
Cancer name
Colorectal Cancer
Cancer site
Colon, Rectum, and Anus
Treatment type
Chemotherapy
Drug
Cetuximab
Impact of wild-type ncRNA on chemotherapy resistance
Down
Impact of knockdown of ncRNA on chemotherapy resistance
Impact of overexpression of ncRNA on chemotherapy resistance
ncRNA differential expression in
cancer
patients vs. healthy people
Down
Number of patients
Not available
Male patients
Not available
Female patients
Not available
Age range and number
Not available
PMID
Description
MiR-302a acts as a multifaceted regulator of CRC metastasis and CTX resistance by targeting NFIB and CD44, respectively.
Tissue resource
fresh paired human colorectal cancer tissues and the corresponding adjacent nontumorous colorectal tissues
human colorectal cancer cell lines HCT116
human colorectal cancer cell lines DiFi
human colorectal cancer cell lines HCT8
human colorectal cancer cell lines HT29
human colorectal cancer cell lines LoVo
human colorectal cancer cell lines RKO
human colorectal cancer cell lines DLD-1
human colorectal cancer cell lines SW620
human colorectal cancer cell lines SW480
human colorectal cancer cell lines Caco-2
human colorectal cancer cell lines SW1463
human colorectal cancer cell lines T84
human colorectal cancer cell lines SW948
normal human intestinal epithelial cell lines HIEC
Experiment
qRT-PCR,Dual-Luciferase reporter assay
Institute
Xijing Hospital of Digestive Diseases
American Type Culture Collection
Country
China
USA
Continent
Asia
North American
Institutes for Systems Genetics, West China Hospital
Copyright @ 2022 ISG. All Rights Reserved.