HAND2-AS1

ncRNA information

ncRNA name

HAND2-AS1

Specific or universal ncRNAs

Specific ncRNAs

Class

Long noncoding RNA

Biomarker

No

Biomarker application

Upstream regulatory factors

Not available

Downstream target

miR-20a/PDCD4

Cancer information

Cancer name

Colorectal Cancer

Cancer site

Colon, Rectum, and Anus

Treatment information

Treatment type

Chemotherapy

Drug

5-Fluorouracil

Impact of wild-type ncRNA on chemotherapy resistance

Down

Impact of knockdown of ncRNA on chemotherapy resistance

Impact of overexpression of ncRNA on chemotherapy resistance

Clinical Information

ncRNA differential expression in
cancer patients vs. healthy people

Not available

Number of patients

Not available

Male patients

Not available

Female patients

Not available

Age range and number

Not available

Research information

PMID

Description

HAND2-AS1/miR-20a/PDCD4 inhibited cell progression and 5-FU resistance in 5-FU-resistant CRC cells.

Tissue resource

colorectal cancer tissues and paratumor tissues

human normal colonic epithelial cell lines NCM460

colorectal cancer cell lines HCT116

colorectal cancer cell lines SW480

Experiment

qRT-PCR,Western blot,Dual-Luciferase reporter assay


Institute

The Sixth Affiliated Hospital of Sun Yat-sen University

BeNa Culture Collection

National Infrastructure of Cell Line Resource

Country

China

Continent

Asia