Institutes for Systems Genetics, West China Hospital
Copyright @ 2022 ISG. All Rights Reserved.
ncRNA name
HAND2-AS1
Specific or universal ncRNAs
Specific ncRNAs
Class
Long noncoding RNA
Biomarker
No
Biomarker application
Upstream regulatory factors
Not available
Downstream target
miR-20a/PDCD4
Cancer name
Colorectal Cancer
Cancer site
Colon, Rectum, and Anus
Treatment type
Chemotherapy
Drug
5-Fluorouracil
Impact of wild-type ncRNA on chemotherapy resistance
Down
Impact of knockdown of ncRNA on chemotherapy resistance
Impact of overexpression of ncRNA on chemotherapy resistance
ncRNA differential expression in
cancer
patients vs. healthy people
Not available
Number of patients
Not available
Male patients
Not available
Female patients
Not available
Age range and number
Not available
PMID
Description
HAND2-AS1/miR-20a/PDCD4 inhibited cell progression and 5-FU resistance in 5-FU-resistant CRC cells.
Tissue resource
colorectal cancer tissues and paratumor tissues
human normal colonic epithelial cell lines NCM460
colorectal cancer cell lines HCT116
colorectal cancer cell lines SW480
Experiment
qRT-PCR,Western blot,Dual-Luciferase reporter assay
Institute
The Sixth Affiliated Hospital of Sun Yat-sen University
BeNa Culture Collection
National Infrastructure of Cell Line Resource
Country
China
Continent
Asia
Institutes for Systems Genetics, West China Hospital
Copyright @ 2022 ISG. All Rights Reserved.