Institutes for Systems Genetics, West China Hospital
Copyright @ 2022 ISG. All Rights Reserved.
ncRNA name
FOXD2-AS1
Specific or universal ncRNAs
Universal ncRNAs
Class
Long noncoding RNA
Biomarker
No
Biomarker application
Upstream regulatory factors
Not available
Downstream target
miR-98-5p/CPEB4
Cancer name
Glioma
Cancer site
Brain, Central Nervous System
Treatment type
Chemotherapy
Drug
Temozolomide
Impact of wild-type ncRNA on chemotherapy resistance
Impact of knockdown of ncRNA on chemotherapy resistance
Down
Impact of overexpression of ncRNA on chemotherapy resistance
ncRNA differential expression in
cancer
patients vs. healthy people
Up
Number of patients
86
Male patients
52
Female patients
34
Age range and number
45(<60)+41(>=60)
PMID
Description
Silence of FOXD2-AS1 suppressed proliferation and drug resistance and promoted apoptosis of drug-resistant glioma cells. Overexpressed FOXD2-AS1 presented an opposite trend.
Tissue resource
glioma tumor tissues and corresponding para normal tissues
human normal glial brain cell lines HEB
human glioma cell lines U87
human glioma cell lines U251
human glioma cell lines LN229
human glioma cell lines A172
Experiment
qRT-PCR,Western blot,Dual-Luciferase reporter assay
Institute
Jiaotong University Health Science Center
Shanghai Institute of Cells of Chinese Academy of Sciences
Country
China
Continent
Asia
Institutes for Systems Genetics, West China Hospital
Copyright @ 2022 ISG. All Rights Reserved.