hsa-miR-31-3p

ncRNA information

ncRNA name

hsa-miR-31-3p

Specific or universal ncRNAs

Specific ncRNAs

Class

MicroRNA

Biomarker

No

Biomarker application

Upstream regulatory factors

Not available

Downstream target

Sema4C

Cancer information

Cancer name

Cervical Cancer

Cancer site

Cervix Uteri

Treatment information

Treatment type

Chemotherapy

Drug

Cisplatin

Impact of wild-type ncRNA on chemotherapy resistance

Impact of knockdown of ncRNA on chemotherapy resistance

Impact of overexpression of ncRNA on chemotherapy resistance

Down

Clinical Information

ncRNA differential expression in
cancer patients vs. healthy people

Not available

Number of patients

Not available

Male patients

Not available

Female patients

Not available

Age range and number

Not available

Research information

PMID

Description

Sema4C promoted EMT-mediated cisplatin resistance in cervical cancer cells and that this effect was inhibited by overexpression of miR-31-3p.

Tissue resource

paired human cervical cancer and adjacent nontumor cervical tissues

human cervical cancer cell lines HeLa

human cervical cancer cell lines Caski

human cervical cancer cell lines Siha

human cervical cancer cell lines C33a

Experiment

qRT-PCR,Western blot,Dual-Luciferase reporter assay


Institute

the Tongji Hospital Affiliated with the Tongji Medical College of Huazhong University of Science and Technology

the Institute of Biochemistry and Cell Biology,Chinese Academy of Sciences

Country

China

Continent

Asia