Institutes for Systems Genetics, West China Hospital
Copyright @ 2022 ISG. All Rights Reserved.
ncRNA name
hsa-miR-31-3p
Specific or universal ncRNAs
Specific ncRNAs
Class
MicroRNA
Biomarker
No
Biomarker application
Upstream regulatory factors
Not available
Downstream target
Sema4C
Cancer name
Cervical Cancer
Cancer site
Cervix Uteri
Treatment type
Chemotherapy
Drug
Cisplatin
Impact of wild-type ncRNA on chemotherapy resistance
Impact of knockdown of ncRNA on chemotherapy resistance
Impact of overexpression of ncRNA on chemotherapy resistance
Down
ncRNA differential expression in
cancer
patients vs. healthy people
Not available
Number of patients
Not available
Male patients
Not available
Female patients
Not available
Age range and number
Not available
PMID
Description
Sema4C promoted EMT-mediated cisplatin resistance in cervical cancer cells and that this effect was inhibited by overexpression of miR-31-3p.
Tissue resource
paired human cervical cancer and adjacent nontumor cervical tissues
human cervical cancer cell lines HeLa
human cervical cancer cell lines Caski
human cervical cancer cell lines Siha
human cervical cancer cell lines C33a
Experiment
qRT-PCR,Western blot,Dual-Luciferase reporter assay
Institute
the Tongji Hospital Affiliated with the Tongji Medical College of Huazhong University of Science and Technology
the Institute of Biochemistry and Cell Biology,Chinese Academy of Sciences
Country
China
Continent
Asia
Institutes for Systems Genetics, West China Hospital
Copyright @ 2022 ISG. All Rights Reserved.