PCAT-1

ncRNA information

ncRNA name

PCAT-1

Specific or universal ncRNAs

Universal ncRNAs

Class

Long noncoding RNA

Biomarker

Yes

Biomarker application

Treatment

Upstream regulatory factors

Not available

Downstream target

p38/JNK MAPK

Cancer information

Cancer name

Myeloma

Cancer site

Multiple Myeloma

Treatment information

Treatment type

Chemotherapy

Drug

Bortezomib

Impact of wild-type ncRNA on chemotherapy resistance

Impact of knockdown of ncRNA on chemotherapy resistance

Down

Impact of overexpression of ncRNA on chemotherapy resistance

Clinical Information

ncRNA differential expression in
cancer patients vs. healthy people

Up

Number of patients

Not available

Male patients

Not available

Female patients

Not available

Age range and number

Not available

Research information

PMID

Description

PCAT-1 facilitated cell growth and drug resistance via the p38 and JNK MAPK pathways.

Tissue resource

multiple myeloma samples

human multiple myeloma cell lines NCI-H929

human multiple myeloma cell lines RIMP 8226

human multiple myeloma cell lines U266

Experiment

qRT-PCR


Institute

the affiliated hospital of Nantong University

Country

China

Continent

Asia