Institutes for Systems Genetics, West China Hospital
Copyright @ 2022 ISG. All Rights Reserved.
ncRNA name
CCAT2
Specific or universal ncRNAs
Universal ncRNAs
Class
Long noncoding RNA
Biomarker
Yes
Biomarker application
Treatment
Upstream regulatory factors
Not available
Downstream target
miR-145/p70S6K1/p53
Cancer name
Esophageal Cancer
Cancer site
Esophagus
Treatment type
Radiotherapy
Impact of wild-type ncRNA on radiotherapy resistance
Up
ncRNA differential expression in
cancer
patients vs. healthy people
Up
Number of patients
Not available
Male patients
Not available
Female patients
Not available
Age range and number
Not available
PMID
Description
These results showed that CCAT2 promoted the radiotherapy resistance of EC cells via negative regulation of the miR-145/p70S6K1 and the p53 signaling pathways and associated elements may be potential targets for improving the sensitivity of EC radiotherapy.
Tissue resource
esophageal cancer tissue and healthy esophageal mucosa
esophageal cancer cell lines HEEC
esophageal cancer cell lines TE-1
esophageal cancer cell lines TE-3
esophageal cancer cell lines ECA109
esophageal cancer cell lines KYSE410
esophageal cancer cell lines KYSE520
Experiment
qRT-PCR,Western blot,Dual-Luciferase reporter assay
Institute
Cangzhou Central Hospital Hospital
the Cell Bank of Type Culture Collection of the Chinese Academy of Sciences
Country
China
Continent
Asia
Institutes for Systems Genetics, West China Hospital
Copyright @ 2022 ISG. All Rights Reserved.