CCAT2

ncRNA information

ncRNA name

CCAT2

Specific or universal ncRNAs

Universal ncRNAs

Class

Long noncoding RNA

Biomarker

Yes

Biomarker application

Treatment

Upstream regulatory factors

Not available

Downstream target

miR-145/p70S6K1/p53

Cancer information

Cancer name

Esophageal Cancer

Cancer site

Esophagus

Treatment information

Treatment type

Radiotherapy

Impact of wild-type ncRNA on radiotherapy resistance

Up

Clinical Information

ncRNA differential expression in
cancer patients vs. healthy people

Up

Number of patients

Not available

Male patients

Not available

Female patients

Not available

Age range and number

Not available

Research information

PMID

Description

These results showed that CCAT2 promoted the radiotherapy resistance of EC cells via negative regulation of the miR-145/p70S6K1 and the p53 signaling pathways and associated elements may be potential targets for improving the sensitivity of EC radiotherapy.

Tissue resource

esophageal cancer tissue and healthy esophageal mucosa

esophageal cancer cell lines HEEC

esophageal cancer cell lines TE-1

esophageal cancer cell lines TE-3

esophageal cancer cell lines ECA109

esophageal cancer cell lines KYSE410

esophageal cancer cell lines KYSE520

Experiment

qRT-PCR,Western blot,Dual-Luciferase reporter assay


Institute

Cangzhou Central Hospital Hospital

the Cell Bank of Type Culture Collection of the Chinese Academy of Sciences

Country

China

Continent

Asia