Institutes for Systems Genetics, West China Hospital
Copyright @ 2022 ISG. All Rights Reserved.
ncRNA name
hsa-let-7f
Specific or universal ncRNAs
Specific ncRNAs
Class
MicroRNA
Biomarker
No
Biomarker application
Upstream regulatory factors
Not available
Downstream target
ABCC5/ABCC10
Cancer name
Leukemia
Cancer site
Leukemia
Treatment type
Chemotherapy
Drug
Adriamycin
Impact of wild-type ncRNA on chemotherapy resistance
Impact of knockdown of ncRNA on chemotherapy resistance
Impact of overexpression of ncRNA on chemotherapy resistance
Down
ncRNA differential expression in
cancer
patients vs. healthy people
Not available
Number of patients
Not available
Male patients
Not available
Female patients
Not available
Age range and number
Not available
PMID
Description
The let-7f downregulation induced the ADR resistance of leukemia by upregulating ABCC5 and ABCC10 expression.
Tissue resource
human leukemia cell lines K562
human multidrug-resistant leukemia cell lines K562/A02
Experiment
qRT-PCR,Western blot,Dual-Luciferase reporter assay
Institute
American Type Culture Collection
Country
USA
Continent
North American
Institutes for Systems Genetics, West China Hospital
Copyright @ 2022 ISG. All Rights Reserved.