CTRR-ncRNA

ncRNA information

ncRNA name

hsa_circ_0001821

Specific or universal ncRNAs

Universal ncRNAs

Class

Circular RNA

Biomarker

Yes

Biomarker application

Treatment

Upstream regulatory factors

Not available

Downstream target

miRNA-124-3p/ZEB1

Cancer information

Cancer name

Gastric Cancer

Cancer site

Stomach

Treatment information

Treatment type

Chemotherapy

Drug

Paclitaxel

Impact of wild-type ncRNA on chemotherapy resistance

Up

Impact of knockdown of ncRNA on chemotherapy resistance

Down

Impact of overexpression of ncRNA on chemotherapy resistance

Clinical Information

ncRNA differential expression in
cancer patients vs. healthy people

Not available

Number of patients

Not available

Male patients

Not available

Female patients

Not available

Age range and number

Not available

Research information

PMID

31793989

Description

Circ-PVT1 facilitated PTX resistance by up-regulating ZEB1 mediated via miR-124-3p, suggesting an underlying therapeutic strategy for GC.

Tissue resource

paclitaxel-resistant gastric cancer tissues and adjacent paclitaxel-sensitive gastric cancer tissues

normal human gastric epithelial cell lines GES-1

human gastric cancer tumor cell lines MKN-45

human gastric cancer tumor cell lines HGC-27

human gastric cancer tumor cell lines MGC-803

human gastric cancer tumor cell lines AGS

Experiment

RT-PCR,Western blot

Institute

the Yantaishan Hospital

Innovation Biotechnology Co., Ltd

Otwo Biotech Co., Ltd

Country

China

Continent

Asia