Institutes for Systems Genetics, West China Hospital
Copyright @ 2022 ISG. All Rights Reserved.
ncRNA name
HOST2
Specific or universal ncRNAs
Universal ncRNAs
Class
Long noncoding RNA
Biomarker
No
Biomarker application
Upstream regulatory factors
Not available
Downstream target
miRNA-621
Cancer name
Non-Small Cell Lung Cancer
Cancer site
Lung
Treatment type
Chemotherapy
Drug
Gefitinib
Impact of wild-type ncRNA on chemotherapy resistance
Up
Impact of knockdown of ncRNA on chemotherapy resistance
Impact of overexpression of ncRNA on chemotherapy resistance
ncRNA differential expression in
cancer
patients vs. healthy people
Not available
Number of patients
Not available
Male patients
Not available
Female patients
Not available
Age range and number
Not available
PMID
Description
HOST2 elevates gefitinib-resistance in NSCLC by degrading miRNA-621 to upregulate SYF2.
Tissue resource
human bronchial epithelial cell lines HBE
human lung adenocarcinoma cell lines A549
non-small cell lung cancer cisplatin-resistant cell line A549/DDP
non-small cell lung cancer paclitaxel-resistant cell line A549/R
EGFR-sensitive mutant lung adenocarcinoma cell lines PC9
EGFR T790M lung adenocarcinoma cell lines H1975
non-small cell lung cancer gefitinib-resistant PC9 cell lines PC9/GR
non-small cell lung cancer gefitinib-resistant PC9 cell lines EGFR
non-small cell lung cancer gefitinib-resistant PC9 cell lines T790M
Experiment
qRT-PCR,Western blot,Dual-Luciferase reporter assay
Institute
China-Japan Union Hospital of Jilin University
Country
China
Continent
Asia
Institutes for Systems Genetics, West China Hospital
Copyright @ 2022 ISG. All Rights Reserved.