hsa-miR-762

ncRNA information

ncRNA name

hsa-miR-762

Specific or universal ncRNAs

Specific ncRNAs

Class

MicroRNA

Biomarker

No

Biomarker application

Upstream regulatory factors

Not available

Downstream target

ABR

Cancer information

Cancer name

Non-Small Cell Lung Cancer

Cancer site

Lung

Treatment information

Treatment type

Chemotherapy

Drug

Gefitinib

Impact of wild-type ncRNA on chemotherapy resistance

Up

Impact of knockdown of ncRNA on chemotherapy resistance

Impact of overexpression of ncRNA on chemotherapy resistance

Clinical Information

ncRNA differential expression in
cancer patients vs. healthy people

Not available

Number of patients

Not available

Male patients

Not available

Female patients

Not available

Age range and number

Not available

Research information

PMID

Description

MiR-762 inhibition and ABR restoration cotreatment in patients with recurrent EGFR mutant NSCLC to therapeutically combat the heterogeneity of EGFR-TKIs resistance mechanisms.

Tissue resource

non-small cell lung cancer tissue samples

human non-small cell lung cancer cell lines A549

human non-small cell lung cancer cell lines NCI-H820

human non-small cell lung cancer cell lines NCI-H2170

human non-small cell lung cancer cell lines NCI-H1650

human non-small cell lung cancer cell lines NCI-H1993

human non-small cell lung cancer cell lines NCI-H2126

human non-small cell lung cancer cell lines NCI-H1975

human non-small cell lung cancer cell lines NCI-H1299

human non-small cell lung cancer cell lines NCI-H1648

human non-small cell lung cancer cell lines NCI-H1703

human non-small cell lung cancer cell lines NCI-H2347

normal human lung epithelial cell lines NuLi-1

Experiment

qRT-PCR,Luciferase reporter assay


Institute

the Second Affiliated Hospital of Xi'an Medical University

American Type Culture Collection

American Type Culture Collection

American Type Culture Collection

American Type Culture Collection

American Type Culture Collection

American Type Culture Collection

American Type Culture Collection

American Type Culture Collection

American Type Culture Collection

American Type Culture Collection

American Type Culture Collection

American Type Culture Collection

Country

China

USA

Continent

Asia

North American