hsa-miR-200b

ncRNA information

ncRNA name

hsa-miR-200b

Specific or universal ncRNAs

Universal ncRNAs

Class

MicroRNA

Biomarker

No

Biomarker application

Upstream regulatory factors

Not available

Downstream target

MYB

Cancer information

Cancer name

Breast Cancer

Cancer site

Breast

Treatment information

Treatment type

Chemotherapy

Drug

Tamoxifen

Impact of wild-type ncRNA on chemotherapy resistance

Impact of knockdown of ncRNA on chemotherapy resistance

Impact of overexpression of ncRNA on chemotherapy resistance

Down

Clinical Information

ncRNA differential expression in
cancer patients vs. healthy people

Not available

Number of patients

Not available

Male patients

Not available

Female patients

Not available

Age range and number

Not available

Research information

PMID

Description

C-MYB was up-regulated in tamoxifen resistant cells and its silencing significantly decreased resistance to tamoxifen and the EMT markers.

Tissue resource

breast cancer cell lines MCF-7

breast cancer tamoxifen resistant cell lines TAM-MCF7

breast cancer cell lines MCF-7

breast cancer tamoxifen resistant cell lines TAM-MCF7

Experiment

qRT-PCR


Institute

Beijing Zhongyuan Limited

Beijing Zhongyuan Limited

Beijing Zhongyuan Limited

Beijing Zhongyuan Limited

Country

China

Continent

Asia