Institutes for Systems Genetics, West China Hospital
Copyright @ 2022 ISG. All Rights Reserved.
ncRNA name
HNF1A-AS1
Specific or universal ncRNAs
Universal ncRNAs
Class
Long noncoding RNA
Biomarker
No
Biomarker application
Upstream regulatory factors
Not available
Downstream target
Not available
Cancer name
Cervical Cancer
Cancer site
Cervix Uteri
Treatment type
Chemotherapy
Drug
Cisplatin
Impact of wild-type ncRNA on chemotherapy resistance
Up
Impact of knockdown of ncRNA on chemotherapy resistance
Impact of overexpression of ncRNA on chemotherapy resistance
ncRNA differential expression in
cancer
patients vs. healthy people
Not available
Number of patients
Not available
Male patients
Not available
Female patients
Not available
Age range and number
Not available
PMID
Description
CC-secreted exosomes carrying HNF1A-AS1 as a ceRNA of miR-34b to promote the expression of TUFT1, thereby promoting the DDP resistance in CC cell.
Tissue resource
human normal cervical epithelial cell lines HcerEpic
cervical cancer DDP-sensitive cell lines HeLa/S
cervical cancer cisplatin-resistant cell lines HeLa/DDP
Experiment
qRT-PCR,Western blot,Dual-Luciferase reporter assay
Institute
the Cell Bank of the Chinese Academy of Sciences
the Cell Bank of the Chinese Academy of Sciences
the Cell Bank of the Chinese Academy of Sciences
Country
China
Continent
Asia
Institutes for Systems Genetics, West China Hospital
Copyright @ 2022 ISG. All Rights Reserved.