MALAT1

ncRNA information

ncRNA name

MALAT1

Specific or universal ncRNAs

Universal ncRNAs

Class

Long noncoding RNA

Biomarker

No

Biomarker application

Upstream regulatory factors

Not available

Downstream target

Not available

Cancer information

Cancer name

Laryngeal Squamous Cell Carcinoma

Cancer site

Larynx

Treatment information

Treatment type

Chemotherapy

Drug

Cisplatin

Impact of wild-type ncRNA on chemotherapy resistance

Up

Impact of knockdown of ncRNA on chemotherapy resistance

Impact of overexpression of ncRNA on chemotherapy resistance

Clinical Information

ncRNA differential expression in
cancer patients vs. healthy people

Not available

Number of patients

Not available

Male patients

Not available

Female patients

Not available

Age range and number

Not available

Research information

PMID

Description

LncRNA MALAT1 counted in triggering tolerance of LSCC against chemo-drugs by boosting metastasis and depressing apoptosis of tumor cells.

Tissue resource

tumor tissues and normal laryngeal mucosa tissues

human laryngeal cancer cell lines TU686

human laryngeal cancer cell lines TU177

human laryngeal cancer cell lines AMC-HN-8

human laryngeal cancer cell lines LSC-1

normal human bronchial epithelial cells NHBEC

Experiment

qRT-PCR,Western blot


Institute

the Yunnan Cancer Hospital

Bena culture collection

Bena culture collection

Bena culture collection

Bena culture collection

Bena culture collection

Country

China

Continent

Asia