Institutes for Systems Genetics, West China Hospital
Copyright @ 2022 ISG. All Rights Reserved.
ncRNA name
MALAT1
Specific or universal ncRNAs
Universal ncRNAs
Class
Long noncoding RNA
Biomarker
No
Biomarker application
Upstream regulatory factors
Not available
Downstream target
Not available
Cancer name
Laryngeal Squamous Cell Carcinoma
Cancer site
Larynx
Treatment type
Chemotherapy
Drug
Cisplatin
Impact of wild-type ncRNA on chemotherapy resistance
Up
Impact of knockdown of ncRNA on chemotherapy resistance
Impact of overexpression of ncRNA on chemotherapy resistance
ncRNA differential expression in
cancer
patients vs. healthy people
Not available
Number of patients
Not available
Male patients
Not available
Female patients
Not available
Age range and number
Not available
PMID
Description
LncRNA MALAT1 counted in triggering tolerance of LSCC against chemo-drugs by boosting metastasis and depressing apoptosis of tumor cells.
Tissue resource
tumor tissues and normal laryngeal mucosa tissues
human laryngeal cancer cell lines TU686
human laryngeal cancer cell lines TU177
human laryngeal cancer cell lines AMC-HN-8
human laryngeal cancer cell lines LSC-1
normal human bronchial epithelial cells NHBEC
Experiment
qRT-PCR,Western blot
Institute
the Yunnan Cancer Hospital
Bena culture collection
Bena culture collection
Bena culture collection
Bena culture collection
Bena culture collection
Country
China
Continent
Asia
Institutes for Systems Genetics, West China Hospital
Copyright @ 2022 ISG. All Rights Reserved.