Institutes for Systems Genetics, West China Hospital
Copyright @ 2022 ISG. All Rights Reserved.
ncRNA name
hsa-miR-770-5p
Specific or universal ncRNAs
Specific ncRNAs
Class
MicroRNA
Biomarker
No
Biomarker application
Upstream regulatory factors
Not available
Downstream target
HIPK1
Cancer name
Colorectal Adenocarcinoma
Cancer site
Colon, Rectum, and Anus
Treatment type
Chemotherapy
Drug
Methotrexate
Impact of wild-type ncRNA on chemotherapy resistance
Up
Impact of knockdown of ncRNA on chemotherapy resistance
Impact of overexpression of ncRNA on chemotherapy resistance
ncRNA differential expression in
cancer
patients vs. healthy people
Not available
Number of patients
Not available
Male patients
Not available
Female patients
Not available
Age range and number
Not available
PMID
Description
Downregulation of miR-770-5p target gene HIPK1 significantly decreased the sensitivity of HT-29 cells to MTX.
Tissue resource
human colorectal adenocarcinoma cell lines HT-29
human colorectal adenocarcinoma HT-29 cell line
Experiment
qRT-PCR,Western blot,Dual-Luciferase reporter assay
Institute
the Cell Bank of Type Culture Collection of the Chinese Academy of Sciences
Cell Bank of Type Culture Collection of Chinese Academy of Sciences
Country
China
China
Continent
Asia
Asia
Institutes for Systems Genetics, West China Hospital
Copyright @ 2022 ISG. All Rights Reserved.