NEAT1

ncRNA information

ncRNA name

NEAT1

Specific or universal ncRNAs

Universal ncRNAs

Class

Long noncoding RNA

Biomarker

No

Biomarker application

Upstream regulatory factors

BCLAF1

Downstream target

Not available

Cancer information

Cancer name

Hepatocellular Carcinoma

Cancer site

Liver

Treatment information

Treatment type

Chemotherapy

Drug

5-Fluorouracil

Impact of wild-type ncRNA on chemotherapy resistance

Up

Impact of knockdown of ncRNA on chemotherapy resistance

Impact of overexpression of ncRNA on chemotherapy resistance

Clinical Information

ncRNA differential expression in
cancer patients vs. healthy people

Not available

Number of patients

Not available

Male patients

Not available

Female patients

Not available

Age range and number

Not available

Research information

PMID

Description

BCLAF1 promoted 5-Fu resistance and the expression of P-gp and MRP1 in hepatocellular carcinoma cells by targeting NEAT1.

Tissue resource

hepatocellular carcinoma cell lines HCCLM3

hepatocellular carcinoma tissues and matched adjacent tissue samples

hepatocellular carcinoma cell lines HL-7702

hepatocellular carcinoma cell lines HuH-7

hepatocellular carcinoma cell lines SMMC-7721

hepatocellular carcinoma cell lines HepG2

Experiment

qRT-PCR,Western blot,Luciferase reporter assay


Institute

Cell Applications

the Yantai Affiliated Hospital of Binzhou Medical University

Cell Applications

Cell Applications

Cell Applications

Cell Applications

Country

China

USA

Continent

Asia

North American