Institutes for Systems Genetics, West China Hospital
Copyright @ 2022 ISG. All Rights Reserved.
ncRNA name
NEAT1
Specific or universal ncRNAs
Universal ncRNAs
Class
Long noncoding RNA
Biomarker
No
Biomarker application
Upstream regulatory factors
BCLAF1
Downstream target
Not available
Cancer name
Hepatocellular Carcinoma
Cancer site
Liver
Treatment type
Chemotherapy
Drug
5-Fluorouracil
Impact of wild-type ncRNA on chemotherapy resistance
Up
Impact of knockdown of ncRNA on chemotherapy resistance
Impact of overexpression of ncRNA on chemotherapy resistance
ncRNA differential expression in
cancer
patients vs. healthy people
Not available
Number of patients
Not available
Male patients
Not available
Female patients
Not available
Age range and number
Not available
PMID
Description
BCLAF1 promoted 5-Fu resistance and the expression of P-gp and MRP1 in hepatocellular carcinoma cells by targeting NEAT1.
Tissue resource
hepatocellular carcinoma cell lines HCCLM3
hepatocellular carcinoma tissues and matched adjacent tissue samples
hepatocellular carcinoma cell lines HL-7702
hepatocellular carcinoma cell lines HuH-7
hepatocellular carcinoma cell lines SMMC-7721
hepatocellular carcinoma cell lines HepG2
Experiment
qRT-PCR,Western blot,Luciferase reporter assay
Institute
Cell Applications
the Yantai Affiliated Hospital of Binzhou Medical University
Cell Applications
Cell Applications
Cell Applications
Cell Applications
Country
China
USA
Continent
Asia
North American
Institutes for Systems Genetics, West China Hospital
Copyright @ 2022 ISG. All Rights Reserved.