Institutes for Systems Genetics, West China Hospital
Copyright @ 2022 ISG. All Rights Reserved.
ncRNA name
LINC00673
Specific or universal ncRNAs
Specific ncRNAs
Class
Long noncoding RNA
Biomarker
No
Biomarker application
Upstream regulatory factors
Not available
Downstream target
Not available
Cancer name
Prostate Cancer
Cancer site
Prostate
Treatment type
Chemotherapy
Drug
Paclitaxel
Impact of wild-type ncRNA on chemotherapy resistance
Impact of knockdown of ncRNA on chemotherapy resistance
Down
Impact of overexpression of ncRNA on chemotherapy resistance
ncRNA differential expression in
cancer
patients vs. healthy people
Not available
Number of patients
Not available
Male patients
Not available
Female patients
Not available
Age range and number
Not available
PMID
Description
LINC00673 silencing could drive demethylation of the KLF4 gene promoter and thus inhibit the proliferation and drug resistance of prostate cancer cells, suggesting that silencing of LINC00673 and elevation of KLF4 could serve as tumour suppressors in prostate cancer.
Tissue resource
prostate cancer cell lines PC3
prostate cancer cell lines LNCap
prostate cancer cell lines DU145
paclitaxel-resistant cell lines DU145/pr
normal prostate epithelial cell lines RWPE-1
prostate cancer cell lines PC3
prostate cancer cell lines LNCap
prostate cancer cell lines DU145
prostate cancer paclitaxel-resistant cell lines DU145/pr
normal prostate epithelial cell lines RWPE-1
Experiment
qRT-PCR,Western blot,Dual-Luciferase reporter assay
Institute
Cell Resource Center of Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences
Cell Resource Center of Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences
Cell Resource Center of Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences
Cell Resource Center of Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences
Cell Resource Center of Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences
Cell Resource Center of Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences
Country
China
China
Continent
Asia
Asia
Institutes for Systems Genetics, West China Hospital
Copyright @ 2022 ISG. All Rights Reserved.