LINC00673

ncRNA information

ncRNA name

LINC00673

Specific or universal ncRNAs

Specific ncRNAs

Class

Long noncoding RNA

Biomarker

No

Biomarker application

Upstream regulatory factors

Not available

Downstream target

Not available

Cancer information

Cancer name

Prostate Cancer

Cancer site

Prostate

Treatment information

Treatment type

Chemotherapy

Drug

Paclitaxel

Impact of wild-type ncRNA on chemotherapy resistance

Impact of knockdown of ncRNA on chemotherapy resistance

Down

Impact of overexpression of ncRNA on chemotherapy resistance

Clinical Information

ncRNA differential expression in
cancer patients vs. healthy people

Not available

Number of patients

Not available

Male patients

Not available

Female patients

Not available

Age range and number

Not available

Research information

PMID

Description

LINC00673 silencing could drive demethylation of the KLF4 gene promoter and thus inhibit the proliferation and drug resistance of prostate cancer cells, suggesting that silencing of LINC00673 and elevation of KLF4 could serve as tumour suppressors in prostate cancer.

Tissue resource

prostate cancer cell lines PC3

prostate cancer cell lines LNCap

prostate cancer cell lines DU145

paclitaxel-resistant cell lines DU145/pr

normal prostate epithelial cell lines RWPE-1

prostate cancer cell lines PC3

prostate cancer cell lines LNCap

prostate cancer cell lines DU145

prostate cancer paclitaxel-resistant cell lines DU145/pr

normal prostate epithelial cell lines RWPE-1

Experiment

qRT-PCR,Western blot,Dual-Luciferase reporter assay


Institute

Cell Resource Center of Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences

Cell Resource Center of Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences

Cell Resource Center of Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences

Cell Resource Center of Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences

Cell Resource Center of Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences

Cell Resource Center of Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences

Country

China

China

Continent

Asia

Asia