Institutes for Systems Genetics, West China Hospital
Copyright @ 2022 ISG. All Rights Reserved.
ncRNA name
SNHG5
Specific or universal ncRNAs
Universal ncRNAs
Class
Long noncoding RNA
Biomarker
No
Biomarker application
Upstream regulatory factors
Not available
Downstream target
miR-32/DNAJB9
Cancer name
Acute Myeloid Leukemia
Cancer site
Leukemia
Treatment type
Chemotherapy
Drug
Adriamycin
Impact of wild-type ncRNA on chemotherapy resistance
Impact of knockdown of ncRNA on chemotherapy resistance
Down
Impact of overexpression of ncRNA on chemotherapy resistance
ncRNA differential expression in
cancer
patients vs. healthy people
Not available
Number of patients
Not available
Male patients
Not available
Female patients
Not available
Age range and number
Not available
PMID
Description
SHNG5 regulates chemotherapy resistance by targeting the miR-32/DNAJB9 in acute myeloid leukemia, which provided a novel potential target for AML and revealed an important mechanism of chemotherapy resistance.
Tissue resource
peripheral blood from acute myeloid leukemia patients and healthy donors
human acute myeloid leukemia cell lines HL-60
human acute myeloid leukemia cell lines HL-60/ADR
peripheral blood from healthy donors and acute myeloid leukemia patients
human acute myeloid leukemia cell lines HL-60
human acute myeloid leukemia ADR resistant cell lines HL-60/ADR
Experiment
qRT-PCR,Western blot,Luciferase reporter assay
Institute
the Xiangya Hospital of Central South University
the Xiangya School of Medicine Type Culture Collection
Xiangya Hospital of Central South University
Xiangya School of Medicine Type Culture Collection
Country
China
China
China
Continent
Asia
Asia
Asia
Institutes for Systems Genetics, West China Hospital
Copyright @ 2022 ISG. All Rights Reserved.