Institutes for Systems Genetics, West China Hospital
Copyright @ 2022 ISG. All Rights Reserved.
ncRNA name
hsa-miR-106a-3p
Specific or universal ncRNAs
Specific ncRNAs
Class
MicroRNA
Biomarker
No
Biomarker application
Upstream regulatory factors
Not available
Downstream target
JAK2/STAT3
Cancer name
Gastric Cancer
Cancer site
Stomach
Treatment type
Chemotherapy
Drug
Apatinib
Impact of wild-type ncRNA on chemotherapy resistance
Up
Impact of knockdown of ncRNA on chemotherapy resistance
Impact of overexpression of ncRNA on chemotherapy resistance
ncRNA differential expression in
cancer
patients vs. healthy people
Not available
Number of patients
Not available
Male patients
Not available
Female patients
Not available
Age range and number
Not available
PMID
Description
MiR-106a-3p induces apatinib resistance and activates JAK2/STAT3 by targeting SOCS system in gastric cancer. MiR-106a-3p/SOCS plays a potent role in gastric cancer cell resistance to apatinib.
Tissue resource
human gastric cancer cell lines SGC-7901
human gastric cancer cell lines BGC-823
Experiment
qRT-PCR,Western blot,Luciferase reporter assay
Institute
the Cell Bank of Chinese Academy of Science
Country
China
Continent
Asia
Institutes for Systems Genetics, West China Hospital
Copyright @ 2022 ISG. All Rights Reserved.