hsa-miR-106a-3p

ncRNA information

ncRNA name

hsa-miR-106a-3p

Specific or universal ncRNAs

Specific ncRNAs

Class

MicroRNA

Biomarker

No

Biomarker application

Upstream regulatory factors

Not available

Downstream target

JAK2/STAT3

Cancer information

Cancer name

Gastric Cancer

Cancer site

Stomach

Treatment information

Treatment type

Chemotherapy

Drug

Apatinib

Impact of wild-type ncRNA on chemotherapy resistance

Up

Impact of knockdown of ncRNA on chemotherapy resistance

Impact of overexpression of ncRNA on chemotherapy resistance

Clinical Information

ncRNA differential expression in
cancer patients vs. healthy people

Not available

Number of patients

Not available

Male patients

Not available

Female patients

Not available

Age range and number

Not available

Research information

PMID

Description

MiR-106a-3p induces apatinib resistance and activates JAK2/STAT3 by targeting SOCS system in gastric cancer. MiR-106a-3p/SOCS plays a potent role in gastric cancer cell resistance to apatinib.

Tissue resource

human gastric cancer cell lines SGC-7901

human gastric cancer cell lines BGC-823

Experiment

qRT-PCR,Western blot,Luciferase reporter assay


Institute

the Cell Bank of Chinese Academy of Science

Country

China

Continent

Asia