MIAT

ncRNA information

ncRNA name

MIAT

Specific or universal ncRNAs

Specific ncRNAs

Class

Long noncoding RNA

Biomarker

Yes

Biomarker application

Treatment

Upstream regulatory factors

Not available

Downstream target

miR-184

Cancer information

Cancer name

Non-Small Cell Lung Cancer

Cancer site

Lung

Treatment information

Treatment type

Chemotherapy

Drug

Cisplatin

Impact of wild-type ncRNA on chemotherapy resistance

Impact of knockdown of ncRNA on chemotherapy resistance

Down

Impact of overexpression of ncRNA on chemotherapy resistance

Clinical Information

ncRNA differential expression in
cancer patients vs. healthy people

Up

Number of patients

60

Male patients

37

Female patients

23

Age range and number

Not available

Research information

PMID

Description

MIAT functions as a competitive endogenous RNA of miR-184 to modulate SF1 expression in NSCLC, which provides a novel insight into the potential therapeutic application of MIAT in NSCLC progression.

Tissue resource

non-small cell lung cancer tissues and corresponding adjacent normal tissues

human non-small cell lung cancer cell lines H1299

human non-small cell lung cancer CDDP resistant cell lines H1299

non-small cell lung cancer tissues and corresponding adjacent normal tissues

human non-small cell lung cancer cell lines H1299

human non-small cell lung cancer CDDP resistant cell lines H1299-CDDP

Experiment

qRT-PCR,Western blot,Dual-Luciferase reporter assay


Institute

the First Affiliated Hospital of Gannan Medical University

the cell bank of Type Culture Collection of the Chinese Academy of Sciences

First Affiliated Hospital of Gannan Medical University

cell bank of Type Culture Collection of the Chinese Academy of Sciences

Country

China

China

China

Continent

Asia

Asia

Asia