Institutes for Systems Genetics, West China Hospital
Copyright @ 2022 ISG. All Rights Reserved.
ncRNA name
MIAT
Specific or universal ncRNAs
Specific ncRNAs
Class
Long noncoding RNA
Biomarker
Yes
Biomarker application
Treatment
Upstream regulatory factors
Not available
Downstream target
miR-184
Cancer name
Non-Small Cell Lung Cancer
Cancer site
Lung
Treatment type
Chemotherapy
Drug
Cisplatin
Impact of wild-type ncRNA on chemotherapy resistance
Impact of knockdown of ncRNA on chemotherapy resistance
Down
Impact of overexpression of ncRNA on chemotherapy resistance
ncRNA differential expression in
cancer
patients vs. healthy people
Up
Number of patients
60
Male patients
37
Female patients
23
Age range and number
Not available
PMID
Description
MIAT functions as a competitive endogenous RNA of miR-184 to modulate SF1 expression in NSCLC, which provides a novel insight into the potential therapeutic application of MIAT in NSCLC progression.
Tissue resource
non-small cell lung cancer tissues and corresponding adjacent normal tissues
human non-small cell lung cancer cell lines H1299
human non-small cell lung cancer CDDP resistant cell lines H1299
non-small cell lung cancer tissues and corresponding adjacent normal tissues
human non-small cell lung cancer cell lines H1299
human non-small cell lung cancer CDDP resistant cell lines H1299-CDDP
Experiment
qRT-PCR,Western blot,Dual-Luciferase reporter assay
Institute
the First Affiliated Hospital of Gannan Medical University
the cell bank of Type Culture Collection of the Chinese Academy of Sciences
First Affiliated Hospital of Gannan Medical University
cell bank of Type Culture Collection of the Chinese Academy of Sciences
Country
China
China
China
Continent
Asia
Asia
Asia
Institutes for Systems Genetics, West China Hospital
Copyright @ 2022 ISG. All Rights Reserved.