ncRNA name
hsa-miR-221
Specific or universal ncRNAs
Universal ncRNAs
Class
MicroRNA
Biomarker
None
Biomarker application
Upstream regulatory factors
Not available
Downstream target
PTEN/Akt/mTOR
Cancer name
Breast Cancer
Cancer site
qRT-PCR,Western blot
Treatment type
Chemotherapy
Drug
Adriamycin
Impact of wild-type ncRNA on chemotherapy resistance
Up
Impact of knockdown of ncRNA on chemotherapy resistance
Impact of overexpression of ncRNA on chemotherapy resistance
ncRNA differential expression in
cancer
patients vs. healthy people
Not available
Number of patients
Not available
Male patients
Not available
Female patients
Not available
Age range and number
Not available
PMID
Description
MicroRNA-221 promotes breast cancer resistance to adriamycin via modulation of PTEN/Akt/mTOR signaling
Tissue resource
pairs of breast cancer samples as well as their nearby normal tissues
breast cancer cell lines MCF-7
breast cancer adriamycin-resistant cell lines MCF-7/ADR
human breast epithelial cell lines MCF-10A
Experiment
None
Institute
Central Hospital of Zibo
Jiying Biotech
Country
China
China
Continent
Asia
Asia