CTRR-ncRNA

ncRNA information

ncRNA name

hsa-miR-221

Specific or universal ncRNAs

Universal ncRNAs

Class

MicroRNA

Biomarker

None

Biomarker application

Upstream regulatory factors

Not available

Downstream target

PTEN/Akt/mTOR

Cancer information

Cancer name

Breast Cancer

Cancer site

qRT-PCR,Western blot

Treatment information

Treatment type

Chemotherapy

Drug

Adriamycin

Impact of wild-type ncRNA on chemotherapy resistance

Up

Impact of knockdown of ncRNA on chemotherapy resistance

Impact of overexpression of ncRNA on chemotherapy resistance

Clinical Information

ncRNA differential expression in
cancer patients vs. healthy people

Not available

Number of patients

Not available

Male patients

Not available

Female patients

Not available

Age range and number

Not available

Research information

PMID

31899608

Description

MicroRNA-221 promotes breast cancer resistance to adriamycin via modulation of PTEN/Akt/mTOR signaling

Tissue resource

pairs of breast cancer samples as well as their nearby normal tissues

breast cancer cell lines MCF-7

breast cancer adriamycin-resistant cell lines MCF-7/ADR

human breast epithelial cell lines MCF-10A

Experiment

None

Institute

Central Hospital of Zibo

Jiying Biotech

Country

China

Continent

Asia