hsa-miR-7

ncRNA information

ncRNA name

hsa-miR-7

Specific or universal ncRNAs

Universal ncRNAs

Class

MicroRNA

Biomarker

Yes

Biomarker application

Treatment

Upstream regulatory factors

Not available

Downstream target

MRPI/BCL2

Cancer information

Cancer name

Breast Cancer

Cancer site

Breast

Treatment information

Treatment type

Chemotherapy

Drug

Carboplatin/Paclitaxel

Impact of wild-type ncRNA on chemotherapy resistance

Down

Impact of knockdown of ncRNA on chemotherapy resistance

Impact of overexpression of ncRNA on chemotherapy resistance

Clinical Information

ncRNA differential expression in
cancer patients vs. healthy people

Not available

Number of patients

60

Male patients

Not available

Female patients

Not available

Age range and number

Not available

Research information

PMID

Description

MiR-7 reverses breast cancer chemoresistance through suppressing MRP1 and BCL2, and also suggest that miR-7 may possess a predictive value and represent a therapeutic target in breast cancer chemotherapy.

Tissue resource

breast cancer tissues

human breast cancer cell lines MCF-7

human breast cancer cell lines MDA-MB-231

human embryonic kidney cell lines HEK-293T

Experiment

qRT-PCR,Western blot,Luciferase reporter assay


Institute

Jinjiang Hospital of Quanzhou Medical College

American Type Culture Collection

Country

China

USA

Continent

Asia

North American