HOTTIP

ncRNA information

ncRNA name

HOTTIP

Specific or universal ncRNAs

Universal ncRNAs

Class

Long noncoding RNA

Biomarker

Yes

Biomarker application

Treatment

Upstream regulatory factors

Not available

Downstream target

HMGA1/miR-218

Cancer information

Cancer name

Gastric Cancer

Cancer site

Stomach

Treatment information

Treatment type

Chemotherapy

Drug

Cisplatin

Impact of wild-type ncRNA on chemotherapy resistance

Impact of knockdown of ncRNA on chemotherapy resistance

Down

Impact of overexpression of ncRNA on chemotherapy resistance

Clinical Information

ncRNA differential expression in
cancer patients vs. healthy people

Not available

Number of patients

58

Male patients

Not available

Female patients

Not available

Age range and number

31(<60)+27(>=60)

Research information

PMID

Description

Exosomal HOTTIP contributed to cisplatin resistance in GC cells by regulating miR-218/HMGA1 , providing a novel avenue for the treatment of GC.

Tissue resource

serum samples were enrolled from the patients with GC who received cisplatin treatment

human gastric cancer cell lines MGC-803

human gastric cancer cell lines MKN-45

Experiment

qRT-PCR,Western blot,Dual-Luciferase reporter assay


Institute

the Fifth Affiliate Hospital of Sun Yat-Sen University

the Bena culture collection Co., Ltd

Country

China

Continent

Asia