Institutes for Systems Genetics, West China Hospital
Copyright @ 2022 ISG. All Rights Reserved.
ncRNA name
HOTTIP
Specific or universal ncRNAs
Universal ncRNAs
Class
Long noncoding RNA
Biomarker
Yes
Biomarker application
Treatment
Upstream regulatory factors
Not available
Downstream target
HMGA1/miR-218
Cancer name
Gastric Cancer
Cancer site
Stomach
Treatment type
Chemotherapy
Drug
Cisplatin
Impact of wild-type ncRNA on chemotherapy resistance
Impact of knockdown of ncRNA on chemotherapy resistance
Down
Impact of overexpression of ncRNA on chemotherapy resistance
ncRNA differential expression in
cancer
patients vs. healthy people
Not available
Number of patients
58
Male patients
Not available
Female patients
Not available
Age range and number
31(<60)+27(>=60)
PMID
Description
Exosomal HOTTIP contributed to cisplatin resistance in GC cells by regulating miR-218/HMGA1 , providing a novel avenue for the treatment of GC.
Tissue resource
serum samples were enrolled from the patients with GC who received cisplatin treatment
human gastric cancer cell lines MGC-803
human gastric cancer cell lines MKN-45
Experiment
qRT-PCR,Western blot,Dual-Luciferase reporter assay
Institute
the Fifth Affiliate Hospital of Sun Yat-Sen University
the Bena culture collection Co., Ltd
Country
China
Continent
Asia
Institutes for Systems Genetics, West China Hospital
Copyright @ 2022 ISG. All Rights Reserved.