Institutes for Systems Genetics, West China Hospital
Copyright @ 2022 ISG. All Rights Reserved.
ncRNA name
CircNPM1
Specific or universal ncRNAs
Specific ncRNAs
Class
Circular RNA
Biomarker
None
Biomarker application
Upstream regulatory factors
Not available
Downstream target
miR-345-5p/FZD5
Cancer name
Acute Myeloid Leukemia
Cancer site
qRT-PCR,Western blot,Dual-luciferase assay
Treatment type
Chemotherapy
Drug
Adriamycin
Impact of wild-type ncRNA on chemotherapy resistance
Up
Impact of knockdown of ncRNA on chemotherapy resistance
Impact of overexpression of ncRNA on chemotherapy resistance
ncRNA differential expression in
cancer
patients vs. healthy people
Up
Number of patients
Not available
Male patients
Not available
Female patients
Not available
Age range and number
Not available
PMID
Description
CircNPM1 strengthens Adriamycin resistance in acute myeloid leukemia by mediating the miR-345-5p/FZD5 pathway
Tissue resource
peripheral blood samples
human acute myeloid leukemia mononuclear cell lines THP-1
human promyelocytic leukemia cell lines HL-60
marrow stromal cell lines HS-5
Experiment
None
Institute
Jingjiang Chinese Medicine Hospital
Bena Culture Collection
Country
China
China
Continent
Asia
Asia
Institutes for Systems Genetics, West China Hospital
Copyright @ 2022 ISG. All Rights Reserved.