Institutes for Systems Genetics, West China Hospital
Copyright @ 2022 ISG. All Rights Reserved.
ncRNA name
hsa_circ_0063809
Specific or universal ncRNAs
Specific ncRNAs
Class
Circular RNA
Biomarker
No
Biomarker application
Upstream regulatory factors
Not available
Downstream target
miR-1252/FOXR2
Cancer name
Ovarian Cancer
Cancer site
Ovary
Treatment type
Chemotherapy
Drug
Paclitaxel
Impact of wild-type ncRNA on chemotherapy resistance
Up
Impact of knockdown of ncRNA on chemotherapy resistance
Down
Impact of overexpression of ncRNA on chemotherapy resistance
ncRNA differential expression in
cancer
patients vs. healthy people
Not available
Number of patients
Not available
Male patients
Not available
Female patients
Not available
Age range and number
Not available
PMID
Description
We identified circCELSR1 to be dramatically highly expressed in ovarian cancer samples and correlated with PTX resistance. Compared with sensitive cell lines, circCELSR1 was also highly expressed in PTX-resistant ovarian cancer cell lines, and circCELSR1 silencing enhanced PTX-induced cytotoxicity in ovarian cancer cells.
Tissue resource
ovarian carcinoma specimens
human ovarian carcinoma cell lines SKOV3
human ovarian carcinoma cell lines HeyA-8
normal ovarian epithelial cell lines IOSE-80
ovarian carcinoma specimens
human ovarian carcinoma cell lines SKOV3
human ovarian carcinoma cell lines HeyA-8
normal ovarian epithelial cell lines IOSE-80
Experiment
qRT-PCR,Western blot,Luciferase reporter assay
Institute
Fudan University Shanghai Cancer Center
American Type Culture Collection
Department of Gynecological Oncology, Fudan University Shanghai Cancer Center
American Type Culture Collection
Country
China
USA
China
United States
Continent
Asia
North American
Asia
North Amercian
Institutes for Systems Genetics, West China Hospital
Copyright @ 2022 ISG. All Rights Reserved.