Institutes for Systems Genetics, West China Hospital
Copyright @ 2022 ISG. All Rights Reserved.
ncRNA name
UCA1
Specific or universal ncRNAs
Universal ncRNAs
Class
Long noncoding RNA
Biomarker
Yes
Biomarker application
Treatment
Upstream regulatory factors
Not available
Downstream target
miR-143/FOSL2
Cancer name
Non-Small Cell Lung Cancer
Cancer site
Lung
Treatment type
Chemotherapy
Drug
Gefitinib
Impact of wild-type ncRNA on chemotherapy resistance
Up
Impact of knockdown of ncRNA on chemotherapy resistance
Down
Impact of overexpression of ncRNA on chemotherapy resistance
ncRNA differential expression in
cancer
patients vs. healthy people
Not available
Number of patients
86
Male patients
46
Female patients
40
Age range and number
34(<60)+52(>=60)
PMID
Description
Our findings indicate that exosomal UCA1 may serve as a promising therapeutic target for the treatment of epidermal growth factor receptor-positive (EGFR+) NSCLC patients.
Tissue resource
non-small cell lung cancer tissues and matched adjacent normal tissues
non-small cell lung cancer cell lines HCC827
non-small cell lung cancer cell lines PC9
human bronchial epithelial cell lines 16HBE
non-small cell lung cancer tissues and matched adjacent normal tissues
non-small cell lung cancer cell lines HCC827
non-small cell lung cancer cell lines PC9
human bronchial epithelial cell lines 16HBE
Experiment
qRT-PCR,Western blot,Luciferase reporter assay
Institute
the Tongji Medical College, Huazhong University of Science and Technology
the Cell Culture Center, Chinese Academy of Medical Sciences
Cancer Center, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
Cell Culture Center, Chinese Academy of Medical Sciences
Country
China
China
China
Continent
Asia
Asia
Asia
Institutes for Systems Genetics, West China Hospital
Copyright @ 2022 ISG. All Rights Reserved.