KCNQ1OT1

ncRNA information

ncRNA name

KCNQ1OT1

Specific or universal ncRNAs

Universal ncRNAs

Class

Long noncoding RNA

Biomarker

No

Biomarker application

Upstream regulatory factors

Not available

Downstream target

miR-124-3p/TRIM14

Cancer information

Cancer name

Tongue Cancer

Cancer site

Tongue

Treatment information

Treatment type

Chemotherapy

Drug

Cisplatin

Impact of wild-type ncRNA on chemotherapy resistance

Impact of knockdown of ncRNA on chemotherapy resistance

Down

Impact of overexpression of ncRNA on chemotherapy resistance

Clinical Information

ncRNA differential expression in
cancer patients vs. healthy people

Not available

Number of patients

Not available

Male patients

Not available

Female patients

Not available

Age range and number

Not available

Research information

PMID

Description

LncRNA KCNQ1OT1 promotes the DDP resistance of tongue cancer by sponging miR-124-3p to regulate TRIM14 expression.

Tissue resource

tongue cancer samples

tongue cancer cell lines CAL27

tongue cancer cell lines SCC9

Experiment

qRT-PCR,Western blot,Microarray microarray,Dual-Luciferase reporter assay


Institute

Jilin University

Beijing Concorde Cell Library

Country

China

Continent

Asia