Institutes for Systems Genetics, West China Hospital
Copyright @ 2022 ISG. All Rights Reserved.
ncRNA name
hsa-miR-146a
Specific or universal ncRNAs
Universal ncRNAs
Class
MicroRNA
Biomarker
No
Biomarker application
Upstream regulatory factors
Not available
Downstream target
NF-ĪŗB signaling pathway
Cancer name
Non-Small Cell Lung Cancer
Cancer site
Lung
Treatment type
Chemotherapy
Drug
Cisplatin
Impact of wild-type ncRNA on chemotherapy resistance
Down
Impact of knockdown of ncRNA on chemotherapy resistance
Impact of overexpression of ncRNA on chemotherapy resistance
ncRNA differential expression in
cancer
patients vs. healthy people
Not available
Number of patients
Not available
Male patients
Not available
Female patients
Not available
Age range and number
Not available
PMID
Description
MiR-146a regulates the DDP sensitivity by inhibiting NF-ĪŗB signaling pathway in NSCLC cells.
Tissue resource
non-small cell lung cancer and adjacent non-tumor tissues
non-small cell lung cancer cell lines A549
non-small cell lung cancer cell lines Calu-1
non-small cell lung cancer cisplatin-resistant cell lines A549/DDP
Experiment
qRT-PCR,Western blot,Luciferase reporter assay
Institute
the Second Hospital of Lanzhou University
American Type Culture Collection
Country
China
USA
Continent
Asia
North American
Institutes for Systems Genetics, West China Hospital
Copyright @ 2022 ISG. All Rights Reserved.