hsa-miR-146a

ncRNA information

ncRNA name

hsa-miR-146a

Specific or universal ncRNAs

Universal ncRNAs

Class

MicroRNA

Biomarker

No

Biomarker application

Upstream regulatory factors

Not available

Downstream target

NF-ĪŗB signaling pathway

Cancer information

Cancer name

Non-Small Cell Lung Cancer

Cancer site

Lung

Treatment information

Treatment type

Chemotherapy

Drug

Cisplatin

Impact of wild-type ncRNA on chemotherapy resistance

Down

Impact of knockdown of ncRNA on chemotherapy resistance

Impact of overexpression of ncRNA on chemotherapy resistance

Clinical Information

ncRNA differential expression in
cancer patients vs. healthy people

Not available

Number of patients

Not available

Male patients

Not available

Female patients

Not available

Age range and number

Not available

Research information

PMID

Description

MiR-146a regulates the DDP sensitivity by inhibiting NF-ĪŗB signaling pathway in NSCLC cells.

Tissue resource

non-small cell lung cancer and adjacent non-tumor tissues

non-small cell lung cancer cell lines A549

non-small cell lung cancer cell lines Calu-1

non-small cell lung cancer cisplatin-resistant cell lines A549/DDP

Experiment

qRT-PCR,Western blot,Luciferase reporter assay


Institute

the Second Hospital of Lanzhou University

American Type Culture Collection

Country

China

USA

Continent

Asia

North American