Institutes for Systems Genetics, West China Hospital
Copyright @ 2022 ISG. All Rights Reserved.
ncRNA name
CircPVT1
Specific or universal ncRNAs
Universal ncRNAs
Class
Circular RNA
Biomarker
None
Biomarker application
Upstream regulatory factors
Not available
Downstream target
miR-145-5p/ABCC1
Cancer name
Lung Adenocarcinoma
Cancer site
qRT-PCR,Western blot,Luciferase assay
Treatment type
Chemotherapy
Drug
Cisplatin/Pemetrexed
Impact of wild-type ncRNA on chemotherapy resistance
Up
Impact of knockdown of ncRNA on chemotherapy resistance
Impact of overexpression of ncRNA on chemotherapy resistance
ncRNA differential expression in
cancer
patients vs. healthy people
Not available
Number of patients
37
Male patients
67
Female patients
52(<63)+52(>=63)
Age range and number
Not available
PMID
Description
CircPVT1 contributes to chemotherapy resistance of lung adenocarcinoma through miR-145-5p/ABCC1 axis
Tissue resource
lung adenocarcinoma and corresponding normal lung tissues
human pulmonary alveolar epithelial cell lines PAEC
human lung adenocarcinoma cell lines PC9
human lung adenocarcinoma cell lines A549
human lung adenocarcinoma drug-resistant cell lines A549/DR
Experiment
104
Institute
Shengjing Hospital
Country
China
Continent
Asia
Institutes for Systems Genetics, West China Hospital
Copyright @ 2022 ISG. All Rights Reserved.