UCA1

ncRNA information

ncRNA name

UCA1

Specific or universal ncRNAs

Universal ncRNAs

Class

Long noncoding RNA

Biomarker

Yes

Biomarker application

Treatment

Upstream regulatory factors

Not available

Downstream target

miR-654-5p/SIK2

Cancer information

Cancer name

Ovarian Cancer

Cancer site

Ovary

Treatment information

Treatment type

Chemotherapy

Drug

Paclitaxel

Impact of wild-type ncRNA on chemotherapy resistance

Impact of knockdown of ncRNA on chemotherapy resistance

Down

Impact of overexpression of ncRNA on chemotherapy resistance

Clinical Information

ncRNA differential expression in
cancer patients vs. healthy people

Not available

Number of patients

31

Male patients

Not available

Female patients

Not available

Age range and number

Not available

Research information

PMID

Description

Silencing of UCA1 restrained the PTX resistance, reduced the proliferation, migration, invasion and enhanced the apoptosis of PTX-resistant OC cells.

Tissue resource

ovarian cancer tissues and adjacent normal tissues from patients

ovarian cancer cell lines A2780

ovarian cancer cell lines OAW42

ovarian cancer cell lines OVCAR4

ovarian cancer cell lines SKOV3

ovarian cancer cell lines HeyA8

human ovarian epithelial cells lines IOSE-386

Experiment

qRT-PCR,Western blot,Microarray microarray,Dual-Luciferase reporter assay


Institute

Gansu Provincial Maternity and Child-Care Hospital

the National for Typical Culture Collection

Country

China

Continent

Asia