Institutes for Systems Genetics, West China Hospital
Copyright @ 2022 ISG. All Rights Reserved.
ncRNA name
UCA1
Specific or universal ncRNAs
Universal ncRNAs
Class
Long noncoding RNA
Biomarker
Yes
Biomarker application
Treatment
Upstream regulatory factors
Not available
Downstream target
miR-654-5p/SIK2
Cancer name
Ovarian Cancer
Cancer site
Ovary
Treatment type
Chemotherapy
Drug
Paclitaxel
Impact of wild-type ncRNA on chemotherapy resistance
Impact of knockdown of ncRNA on chemotherapy resistance
Down
Impact of overexpression of ncRNA on chemotherapy resistance
ncRNA differential expression in
cancer
patients vs. healthy people
Not available
Number of patients
31
Male patients
Not available
Female patients
Not available
Age range and number
Not available
PMID
Description
Silencing of UCA1 restrained the PTX resistance, reduced the proliferation, migration, invasion and enhanced the apoptosis of PTX-resistant OC cells.
Tissue resource
ovarian cancer tissues and adjacent normal tissues from patients
ovarian cancer cell lines A2780
ovarian cancer cell lines OAW42
ovarian cancer cell lines OVCAR4
ovarian cancer cell lines SKOV3
ovarian cancer cell lines HeyA8
human ovarian epithelial cells lines IOSE-386
Experiment
qRT-PCR,Western blot,Microarray microarray,Dual-Luciferase reporter assay
Institute
Gansu Provincial Maternity and Child-Care Hospital
the National for Typical Culture Collection
Country
China
Continent
Asia
Institutes for Systems Genetics, West China Hospital
Copyright @ 2022 ISG. All Rights Reserved.