Exosome LncRNA AFAP1-AS1

ncRNA information

ncRNA name

Exosome LncRNA AFAP1-AS1

Specific or universal ncRNAs

Specific ncRNAs

Class

Long noncoding RNA

Biomarker

None

Biomarker application

Upstream regulatory factors

Not available

Downstream target

AUF1/ERBB2

Cancer information

Cancer name

Breast Cancer

Cancer site

qRT-PCR,Western blot

Treatment information

Treatment type

Chemotherapy

Drug

Trastuzumab

Impact of wild-type ncRNA on chemotherapy resistance

Up

Impact of knockdown of ncRNA on chemotherapy resistance

Impact of overexpression of ncRNA on chemotherapy resistance

Clinical Information

ncRNA differential expression in
cancer patients vs. healthy people

Not available

Number of patients

Not available

Male patients

Not available

Female patients

Not available

Age range and number

Not available

Research information

PMID

Description

Exosome-mediated lncRNA AFAP1-AS1 promotes trastuzumab resistance through binding with AUF1 and activating ERBB2 translation

Tissue resource

serum samples from HER-2 positive patients

human HER-2-positive breast cancer cell lines SKBR-3

human HER-2-positive breast cancer cell lines BT474

Experiment

None


Institute

First Affiliated Hospital of Zhengzhou University

American Type Culture Collection

Country

China

United States

Continent

Asia

North Amercian