hsa-miR-1269b

ncRNA information

ncRNA name

hsa-miR-1269b

Specific or universal ncRNAs

Specific ncRNAs

Class

MicroRNA

Biomarker

Yes

Biomarker application

Treatment

Upstream regulatory factors

Not available

Downstream target

PTEN/PI3K/Akt

Cancer information

Cancer name

Non-Small Cell Lung Cancer

Cancer site

Lung

Treatment information

Treatment type

Chemotherapy

Drug

Cisplatin

Impact of wild-type ncRNA on chemotherapy resistance

Up

Impact of knockdown of ncRNA on chemotherapy resistance

Impact of overexpression of ncRNA on chemotherapy resistance

Up

Clinical Information

ncRNA differential expression in
cancer patients vs. healthy people

Not available

Number of patients

Not available

Male patients

Not available

Female patients

Not available

Age range and number

Not available

Research information

PMID

Description

The miR-1269b/PTEN/PI3K/AKT mediated network might promote cisplatin resistance in NSCLC, and that miR-1269b can be a potential therapeutic target for chemoresistance in NSCLC patients.

Tissue resource

lung tissue samples were obtained from the resected lungs of non-small cell lung cancer patients

non-small cell lung cancer cell lines HA549

non-small cell lung cancer cell lines Sprostate cancer1

non-small cell lung cancer cell lines H1299

non-small cell lung cancer cell lines H358

non-small cell lung cancer cell lines PC9

non-small cell lung cancer cell lines A549/DDP

non-small cell lung cancer cell lines 16HBE

tumor samples with adjacent normal tissues

non-small cell lung cancer cell lines HA549

non-small cell lung cancer cell lines SPCA1

non-small cell lung cancer cell lines H1299

non-small cell lung cancer cell lines H358

non-small cell lung cancer cell lines PC9

non-small cell lung cancer cisplatin-resistant cell lines A549/DDP

non-small cell lung cancer cell lines 16HBE

Experiment

qRT-PCR,Western blot,Luciferase reporter assay


Institute

the First Affiliated Hospital of Nanjing Medical University

the Shanghai Academy of Sciences

First Affiliated Hospital of Nanjing Medical University

Shanghai Academy of Sciences

Country

China

China

China

Continent

Asia

Asia

Asia