PVT1

ncRNA information

ncRNA name

PVT1

Specific or universal ncRNAs

Universal ncRNAs

Class

Long noncoding RNA

Biomarker

Yes

Biomarker application

Treatment

Upstream regulatory factors

Not available

Downstream target

miR-194-5p/HIF1a

Cancer information

Cancer name

Oral Squamous Cell Carcinoma

Cancer site

Lip, Oral Cavity

Treatment information

Treatment type

Chemotherapy

Drug

Cisplatin

Impact of wild-type ncRNA on chemotherapy resistance

Up

Impact of knockdown of ncRNA on chemotherapy resistance

Impact of overexpression of ncRNA on chemotherapy resistance

Clinical Information

ncRNA differential expression in
cancer patients vs. healthy people

Not available

Number of patients

83

Male patients

Not available

Female patients

Not available

Age range and number

Not available

Research information

PMID

Description

HIF1a knock-down or miR-194-5p overexpression reversed PVT1-induced promotion of OSCC cell proliferation and cisplatin resistance.

Tissue resource

oral squamous cell carcinoma tissues

human oral squamous cell carcinoma cell lines SCC9

human oral squamous cell carcinoma cell lines CAL27

human oral squamous cell carcinoma cell lines HEK-293T

tissues from ovarian squamous cell carcinoma patients

human ovarian squamous cell carcinoma cell lines SCC9

human ovarian squamous cell carcinoma cell lines CAL27

human embryonic kidney cell lines 293T

Experiment

qRT-PCR,Western blot,Luciferase reporter assay


Institute

Binzhou Medical University Hospital

the Chinese Academy of Sciences Cell Bank

Binzhou Medical University Hospital

Chinese Academy of Sciences Cell Bank

Country

China

China

China

Continent

Asia

Asia

Asia