Institutes for Systems Genetics, West China Hospital
Copyright @ 2022 ISG. All Rights Reserved.
ncRNA name
PVT1
Specific or universal ncRNAs
Universal ncRNAs
Class
Long noncoding RNA
Biomarker
Yes
Biomarker application
Treatment
Upstream regulatory factors
Not available
Downstream target
miR-194-5p/HIF1a
Cancer name
Oral Squamous Cell Carcinoma
Cancer site
Lip, Oral Cavity
Treatment type
Chemotherapy
Drug
Cisplatin
Impact of wild-type ncRNA on chemotherapy resistance
Up
Impact of knockdown of ncRNA on chemotherapy resistance
Impact of overexpression of ncRNA on chemotherapy resistance
ncRNA differential expression in
cancer
patients vs. healthy people
Not available
Number of patients
83
Male patients
Not available
Female patients
Not available
Age range and number
Not available
PMID
Description
HIF1a knock-down or miR-194-5p overexpression reversed PVT1-induced promotion of OSCC cell proliferation and cisplatin resistance.
Tissue resource
oral squamous cell carcinoma tissues
human oral squamous cell carcinoma cell lines SCC9
human oral squamous cell carcinoma cell lines CAL27
human oral squamous cell carcinoma cell lines HEK-293T
tissues from ovarian squamous cell carcinoma patients
human ovarian squamous cell carcinoma cell lines SCC9
human ovarian squamous cell carcinoma cell lines CAL27
human embryonic kidney cell lines 293T
Experiment
qRT-PCR,Western blot,Luciferase reporter assay
Institute
Binzhou Medical University Hospital
the Chinese Academy of Sciences Cell Bank
Binzhou Medical University Hospital
Chinese Academy of Sciences Cell Bank
Country
China
China
China
Continent
Asia
Asia
Asia
Institutes for Systems Genetics, West China Hospital
Copyright @ 2022 ISG. All Rights Reserved.