Institutes for Systems Genetics, West China Hospital
Copyright @ 2022 ISG. All Rights Reserved.
ncRNA name
Circ_ANKS1B
Specific or universal ncRNAs
Specific ncRNAs
Class
Circular RNA
Biomarker
None
Biomarker application
Upstream regulatory factors
Not available
Downstream target
miR-515-5p
Cancer name
Oral Squamous Cell Carcinoma
Cancer site
qRT-PCR,Western blot,Luciferase assay
Treatment type
Chemotherapy
Drug
Cisplatin
Impact of wild-type ncRNA on chemotherapy resistance
Impact of knockdown of ncRNA on chemotherapy resistance
Impact of overexpression of ncRNA on chemotherapy resistance
ncRNA differential expression in
cancer
patients vs. healthy people
Not available
Number of patients
17
Male patients
13
Female patients
38-65
Age range and number
Not available
PMID
Description
these findings highlight that circANKS1B might act as an oncogenic gene to facilitate the metastatic potential and cisplatin resistance in OSCC by sponging miR-515-5p to regulate TGF-Ī²1
Tissue resource
ovarian squamous cell carcinoma tissue and paired paratumor samples
human ovarian squamous cell carcinoma cell lines CAL27
human ovarian squamous cell carcinoma cell lines SCC9
human ovarian squamous cell carcinoma cell lines SCC090
human normal oral keratinocyte cell line HOK
Experiment
30
Institute
Shaanxi Provincial People’s HospitalShaanxi Provincial People's Hospital
American Type Culture Collection
BeNa Culture Collection
Country
China
United States
China
Continent
Asia
North Amercian
Asia
Institutes for Systems Genetics, West China Hospital
Copyright @ 2022 ISG. All Rights Reserved.