SNHG15

ncRNA information

ncRNA name

SNHG15

Specific or universal ncRNAs

Universal ncRNAs

Class

Long noncoding RNA

Biomarker

Yes

Biomarker application

Treatment

Upstream regulatory factors

Not available

Downstream target

SNHG15

Cancer information

Cancer name

Breast Cancer

Cancer site

Breast

Treatment information

Treatment type

Chemotherapy

Drug

Cisplatin

Impact of wild-type ncRNA on chemotherapy resistance

Up

Impact of knockdown of ncRNA on chemotherapy resistance

Impact of overexpression of ncRNA on chemotherapy resistance

Clinical Information

ncRNA differential expression in
cancer patients vs. healthy people

Not available

Number of patients

Not available

Male patients

Not available

Female patients

Not available

Age range and number

Not available

Research information

PMID

Description

SNHG15 knockdown overcame cisplatin resistance of breast cancer by sponging miR-381, providing a novel therapeutic target for breast cancer.

Tissue resource

paired tumor tissues and adjacent normal tissues were obtained from breast cancer patients

human normal breast epithelial cell lines MCF-10A

human breast cancer cell lines MCF-7

human breast cancer cell lines MDA-MB-231

human breast cancer cisplatin-resistant cell lines MCF-7/DDP

human breast cancer cisplatin-resistant cell lines MDA-MB-231/DDP

paired tumor tissues and adjacent normal tissues obtained from breast cancer patients

human breast cancer cell lines MCF-7

human breast cancer cell lines MDA-MB-231

human normal breast epithelial cell lines MCF-10A

Experiment

qRT-PCR,Luciferase reporter assay


Institute

the First Affiliated Hospital of Zhengzhou University

American Type Culture Collection

First Affiliated Hospital of Zhengzhou University

American Type Culture Collection

Country

China

USA

China

United States

Continent

Asia

North American

Asia

North Amercian