Institutes for Systems Genetics, West China Hospital
Copyright @ 2022 ISG. All Rights Reserved.
ncRNA name
SNHG15
Specific or universal ncRNAs
Universal ncRNAs
Class
Long noncoding RNA
Biomarker
Yes
Biomarker application
Treatment
Upstream regulatory factors
Not available
Downstream target
SNHG15
Cancer name
Breast Cancer
Cancer site
Breast
Treatment type
Chemotherapy
Drug
Cisplatin
Impact of wild-type ncRNA on chemotherapy resistance
Up
Impact of knockdown of ncRNA on chemotherapy resistance
Impact of overexpression of ncRNA on chemotherapy resistance
ncRNA differential expression in
cancer
patients vs. healthy people
Not available
Number of patients
Not available
Male patients
Not available
Female patients
Not available
Age range and number
Not available
PMID
Description
SNHG15 knockdown overcame cisplatin resistance of breast cancer by sponging miR-381, providing a novel therapeutic target for breast cancer.
Tissue resource
paired tumor tissues and adjacent normal tissues were obtained from breast cancer patients
human normal breast epithelial cell lines MCF-10A
human breast cancer cell lines MCF-7
human breast cancer cell lines MDA-MB-231
human breast cancer cisplatin-resistant cell lines MCF-7/DDP
human breast cancer cisplatin-resistant cell lines MDA-MB-231/DDP
paired tumor tissues and adjacent normal tissues obtained from breast cancer patients
human breast cancer cell lines MCF-7
human breast cancer cell lines MDA-MB-231
human normal breast epithelial cell lines MCF-10A
Experiment
qRT-PCR,Luciferase reporter assay
Institute
the First Affiliated Hospital of Zhengzhou University
American Type Culture Collection
First Affiliated Hospital of Zhengzhou University
American Type Culture Collection
Country
China
USA
China
United States
Continent
Asia
North American
Asia
North Amercian
Institutes for Systems Genetics, West China Hospital
Copyright @ 2022 ISG. All Rights Reserved.